STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKB65138.1Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. (450 aa)    
Predicted Functional Partners:
hacB
Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...]
 
 
 0.991
leuC
Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.987
AKB63863.1
Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13.
 
 0.980
AKB64705.1
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase.
  
 
 0.954
AKB63631.1
Beta-ketoacyl synthase/thiolase.
  
 
 0.941
AKB64079.1
2-oxoglutarate oxidoreductase, alpha subunit.
  
 
 0.939
AKB64080.1
2-oxoglutarate oxidoreductase, beta subunit.
  
 
 0.938
AKB66519.1
Pyruvate:ferredoxin oxidoreductase, alpha subunit.
  
 
 0.938
AKB66520.1
Pyruvate:ferredoxin oxidoreductase, beta subunit.
  
 
 0.938
AKB66517.1
Pyruvate:ferredoxin oxidoreductase, gamma subunit.
  
 
 0.935
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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