node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
adeK | b0125 | YPO0378 | YPO3408 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.961 |
adeK | gsk | YPO0378 | YPO3095 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Similar to Escherichia coli inosine-guanosine kinase Gsk SW:INGK_ECOLI (P22937) (434 aa) fasta scores: E(): 0,83.4% id in 434 aa, and to Yersinia enterocolitica inosine-guanosine kinase Gsk TR:Q56875 (EMBL:U46859) (434 aa) fasta scores: E(): 0, 90.3% id in 434 aa. | 0.966 |
adeK | guaA | YPO0378 | YPO2870 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.962 |
adeK | guaB | YPO0378 | YPO2871 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.993 |
adeK | guaC | YPO0378 | YPO3428 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.991 |
adeK | metL | YPO0378 | YPO0116 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Cystathionine gamma-synthase (pseudogene); PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.970 |
adeK | purB | YPO0378 | YPO1636 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Similar to Escherichia coli adenylosuccinate lyase PurB SW:PUR8_ECOLI (P25739) (456 aa) fasta scores: E(): 0,88.6% id in 456 aa, and to Vibrio cholerae adenylosuccinate lyase Vc1126 TR:Q9KSY0 (EMBL:AE004193) (456 aa) fasta scores: E(): 0, 78.5% id in 456 aa. | 0.997 |
adeK | purH | YPO0378 | YPO3728 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Similar to Escherichia coli bifunctional purine biosynthesis protein PurH SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 0, 87.1% id in 529 aa, and to Salmonella typhimurium bifunctional purine biosynthesis protein PurH SW:PUR9_SALTY (P26978) (508 aa) fasta scores: E(): 0, 86.8% id in 508 aa. | 0.996 |
adeK | pyrB | YPO0378 | YPO3588 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Similar to Escherichia coli aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_ECOLI (P00479) (310 aa) fasta scores: E(): 0, 84.8% id in 310 aa,and to Erwinia herbicola aspartate transcarbamylase catalytic subunit PyrB TR:Q9RMS8 (EMBL:AF190426) (311 aa) fasta scores: E(): 0, 85.9% id in 311 aa. | 0.958 |
adeK | thrA | YPO0378 | YPO0459 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I ThrA SW:AK1H_ECOLI (P00561) (820 aa) fasta scores: E(): 0, 82.0% id in 821 aa,and to Serratia marcescens bifunctional aspartokinase/homoserine dehydrogenase I ThrA SW:AK1H_SERMA (P27725) (819 aa) fasta scores: E(): 0, 89.9% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.969 |
b0125 | adeK | YPO3408 | YPO0378 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.961 |
b0125 | gsk | YPO3408 | YPO3095 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Similar to Escherichia coli inosine-guanosine kinase Gsk SW:INGK_ECOLI (P22937) (434 aa) fasta scores: E(): 0,83.4% id in 434 aa, and to Yersinia enterocolitica inosine-guanosine kinase Gsk TR:Q56875 (EMBL:U46859) (434 aa) fasta scores: E(): 0, 90.3% id in 434 aa. | 0.934 |
b0125 | guaA | YPO3408 | YPO2870 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.965 |
b0125 | guaB | YPO3408 | YPO2871 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.948 |
b0125 | guaC | YPO3408 | YPO3428 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.948 |
b0125 | purB | YPO3408 | YPO1636 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Similar to Escherichia coli adenylosuccinate lyase PurB SW:PUR8_ECOLI (P25739) (456 aa) fasta scores: E(): 0,88.6% id in 456 aa, and to Vibrio cholerae adenylosuccinate lyase Vc1126 TR:Q9KSY0 (EMBL:AE004193) (456 aa) fasta scores: E(): 0, 78.5% id in 456 aa. | 0.625 |
b0125 | purH | YPO3408 | YPO3728 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Similar to Escherichia coli bifunctional purine biosynthesis protein PurH SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 0, 87.1% id in 529 aa, and to Salmonella typhimurium bifunctional purine biosynthesis protein PurH SW:PUR9_SALTY (P26978) (508 aa) fasta scores: E(): 0, 86.8% id in 508 aa. | 0.957 |
gsk | adeK | YPO3095 | YPO0378 | Similar to Escherichia coli inosine-guanosine kinase Gsk SW:INGK_ECOLI (P22937) (434 aa) fasta scores: E(): 0,83.4% id in 434 aa, and to Yersinia enterocolitica inosine-guanosine kinase Gsk TR:Q56875 (EMBL:U46859) (434 aa) fasta scores: E(): 0, 90.3% id in 434 aa. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.966 |
gsk | b0125 | YPO3095 | YPO3408 | Similar to Escherichia coli inosine-guanosine kinase Gsk SW:INGK_ECOLI (P22937) (434 aa) fasta scores: E(): 0,83.4% id in 434 aa, and to Yersinia enterocolitica inosine-guanosine kinase Gsk TR:Q56875 (EMBL:U46859) (434 aa) fasta scores: E(): 0, 90.3% id in 434 aa. | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.934 |
gsk | guaA | YPO3095 | YPO2870 | Similar to Escherichia coli inosine-guanosine kinase Gsk SW:INGK_ECOLI (P22937) (434 aa) fasta scores: E(): 0,83.4% id in 434 aa, and to Yersinia enterocolitica inosine-guanosine kinase Gsk TR:Q56875 (EMBL:U46859) (434 aa) fasta scores: E(): 0, 90.3% id in 434 aa. | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.953 |