STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lsrGConserved hypothetical protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family. (96 aa)    
Predicted Functional Partners:
lsrF
Putative aldolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family.
 
  
 0.999
lsrB
Putative periplasmic solute-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
 
  
 0.997
lsrD
Putative ABC transporter permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 
  
 0.986
lsrK
Putative transcriptional regulator (pseudogene); Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
 
  
 0.932
lsrC
Putative ABC transporter permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 
  
 0.920
lsrA
Putative ABC transporter ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (By similarity).
 
  
 0.896
YPO3328
Putative sugar ABC transporter, periplasmic protein; Similar to Escherichia coli from bases 1598243 to 1608845 TR:P76142 (EMBL:AE000249) (340 aa) fasta scores: E(): 1.7e-12, 27.1% id in 306 aa, and to Streptomyces coelicolor putative secreted solute-binding lipoprotein Scf43.19C TR:Q9RD69 (EMBL:AL136502) (360 aa) fasta scores: E(): 1.6e-13, 26.3% id in 319 aa, and to Thermotoga maritima sugar ABC transporter, periplasmic sugar-binding protein Tm0114 TR:Q9WXW9 (EMBL:AE001697) (335 aa) fasta scores: E(): 2.9e-10, 25.4% id in 351 aa.
 
  
 0.844
YPO3633
Putative periplasmic binding protein; Similar to Escherichia coli from bases 1598243 to 1608845 TR:P76142 (EMBL:AE000249) (340 aa) fasta scores: E(): 1e-15, 29.2% id in 312 aa, and to Streptomyces coelicolor putative secreted solute-binding lipoprotein scf43.19C TR:Q9RD69 (EMBL:AL136502) (360 aa) fasta scores: E(): 2.3e-16, 28.3% id in 315 aa.
  
  
 0.842
YPO1813
Similar to Escherichia coli D-allose-binding periplasmic protein precursor AlsB SW:ALSB_ECOLI (P39265) (311 aa) fasta scores: E(): 2.8e-10, 25.8% id in 283 aa,and to Streptomyces coelicolor possible secreted solute-binding lipoprotein Scf51a.27 TR:Q9RL38 (EMBL:AL121596) (359 aa) fasta scores: E(): 2.3e-13, 24.8% id in 303 aa.
  
  
 0.821
YPO1810
Putative transcriptional regulatory protein; Similar to Bacillus subtilis deoxyribonucleoside regulator DeoR SW:DEOR_BACSU (P39140) (313 aa) fasta scores: E(): 9.1e-17, 26.9% id in 305 aa, and to Bacillus halodurans transcriptional regulator BH0780 TR:Q9KER9 (EMBL:AP001509) (316 aa) fasta scores: E(): 3.9e-26, 32.2% id in 304 aa.
 
  
 0.645
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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