STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
b4384Similar to Escherichia coli purine nucleoside phosphorylase DeoD SW:DEOD_ECOLI (P09743) (238 aa) fasta scores: E(): 0, 91.1% id in 236 aa, and to Klebsiella pneumoniae purine nucleoside phosphorylase DeoD SW:DEOD_KLEPN (Q59482) (239 aa) fasta scores: E(): 0, 88.7% id in 238 aa. (239 aa)    
Predicted Functional Partners:
b4383
Thymidine phosphorylase (pseudogene); Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
 
 
 0.990
b0125
Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
 0.985
pndA
Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.977
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
 0.971
gpp
Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
    
 0.971
YPO2295
Haloacid dehalogenase-like hydrolase family protein; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa, and to Escherichia coli hypothetical protein YjjG SW:YJJG_ECOLI (P33999) (225 aa) fasta scores: E(): 0, 56.8% id in 222 aa.
     
 0.964
udp
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family.
 
 
0.960
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
  
 
 0.955
tdk
Thymidine kinase; Similar to Escherichia coli thymidine kinase Tdk SW:KITH_ECOLI (P23331) (205 aa) fasta scores: E(): 0, 76.4% id in 191 aa, and to Vibrio cholerae thymidine kinase VC1167 TR:Q9KST9 (EMBL:AE004197) (192 aa) fasta scores: E(): 0, 72.6% id in 190 aa.
  
 
 0.955
cobB
Putative Sir2 family protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.
    
 0.951
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.