STRINGSTRING
cca protein (Yersinia pestis CO92) - STRING interaction network
"cca" - Multifunctional CCA protein in Yersinia pestis CO92
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
ccaMultifunctional CCA protein; Catalyzes the addition and repair of the essential 3’- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2’- nucleotidase and 2’,3’-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3’-CCA terminus degraded by intracellular RNases (412 aa)    
Predicted Functional Partners:
rnt
Ribonuclease T; Trims short 3’ overhangs of a variety of RNA species, leaving a one or two nucleotide 3’ overhang. Responsible for the end-turnover of tRNA- specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (215 aa)
 
 
  0.934
ams
Ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs; Belongs to the RNase E/G family. RNase E subfamily (1221 aa)
     
  0.930
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5’-leader sequence from pre-tRNA to produce the mature 5’-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5’-leader sequence and broadening the substrate specificity of the ribozyme (119 aa)
   
 
    0.925
rnb
Exoribonuclease 2; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3’ to 5’ direction (644 aa)
     
    0.914
YPO3689
Ribonuclease; PS00070 Aldehyde dehydrogenases cysteine active site (152 aa)
         
    0.900
YPO0651
Putative exported protein; Similar to Escherichia coli hypothetical protein YgiM SW-YGIM_ECOLI (P39202) (206 aa) fasta scores- E()- 0,71.4% id in 206 aa, and to Pseudomonas aeruginosa hypothetical protein PA4154 TR-AAG07541 (EMBL-AE004832) (222 aa) fasta scores- E()- 9.9e-23, 40.1% id in 207 aa. Contains coiled-coil region, residues 126 to 157 (207 aa)
 
        0.893
rnr
Ribonuclease R; 3’-5’ exoribonuclease that releases 5’-nucleoside monophosphates and is involved in maturation of structured RNAs; Belongs to the RNR ribonuclease family. RNase R subfamily (844 aa)
 
 
  0.624
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (932 aa)
   
   
  0.580
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (675 aa)
 
   
  0.570
prlG
Protein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation (127 aa)
   
        0.555
Your Current Organism:
Yersinia pestis CO92
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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