STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
galDUDP-glucose 4-epimerase; Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity). (338 aa)    
Predicted Functional Partners:
galA
Aldose 1-epimerase (pseudogene); Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily.
 
 0.999
galB
Similar to Escherichia coli galactose-1-phosphate uridylyltransferase GalT or GalB SW:GAL7_ECOLI (P09148) (348 aa) fasta scores: E(): 0, 82.4% id in 347 aa.
  
 0.999
galF
Similar to Escherichia coli UTP-glucose-1-phosphate uridylyltransferase SW:GALF_ECOLI (P78083) (297 aa) fasta scores: E(): 0, 65.3% id in 297 aa, and to Klebsiella pneumoniae UTP-glucose-1-phosphate uridylyltransferase GalF SW:GALF_KLEPN (Q48447) (298 aa) fasta scores: E(): 0, 64.3% id in 297 aa. This CDS (GalF) is similar (64.2% in 293 aa overlap) to the adjacent CDS YPO1539 (GalU). Both GalU and GalF have been designated UTP-glucose-1-phosphate uridylyltransferase. However, it has been proposed that GalF is a non-catalytic subunit of the UDP-glucose pyrophosphorylase modulating the e [...]
 
 
 0.970
galU
Similar to Escherichia coli UTP-glucose-1-phosphate uridylyltransferase SW:GALU_ECOLI (P25520) (301 aa) fasta scores: E(): 0, 73.5% id in 294 aa, and to Haemophilus influenzae UTP-glucose-1-phosphate uridylyltransferase GalU or hi0812 SW:GALU_HAEIN (P44878) (295 aa) fasta scores: E(): 0, 71.6% id in 289 aa. This CDS (GalU) is similar (64.2% in 293 aa overlap) to the adjacent CDS, YPO1540 (GalF).
 
  
 0.969
YPO2174
Putative nucleotide sugar dehydrogenase; Similar to Xanthomonas campestris UDP-glucose dehydrogenase TR:Q56812 (EMBL:X79772) (445 aa) fasta scores: E(): 0, 61.3% id in 349 aa, and to Pseudomonas aeruginosa probable nucleotide sugar dehydrogenase PA3559 TR:AAG06947 (EMBL:AE004776) (464 aa) fasta scores: E(): 0,64.9% id in 447 aa.
 
 
 0.963
rffG
dTDP-D-glucose-4,6-dehydratase; Similar to Erwinia carotovora subsp. atroseptica dTDP-D-glucose-4,6-dehydratase RffG TR:O68459 (EMBL:AF044332) (357 aa) fasta scores: E(): 0, 85.4% id in 355 aa, and to Escherichia coli dTDP-glucose 4,6-dehydratase RffG SW:RFFG_ECOLI (P27830) (355 aa) fasta scores: E(): 0, 82.2% id in 353 aa; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
 
 
0.755
lacZ
Beta-galactosidase; Similar to Escherichia coli beta-galactosidase LacZ SW:BGAL_ECOLI (P00722) (1023 aa) fasta scores: E(): 0,62.5% id in 1046 aa, and to Enterobacter cloacae beta-galactosidase lacZ SW:BGAL_ENTCL (Q47077) (1028 aa) fasta scores: E(): 0, 60.4% id in 1046 aa; Belongs to the glycosyl hydrolase 2 family.
  
 
 0.647
rffH
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
    
 0.625
manC
Similar to Yersinia pseudotuberculosis mannose-1-phosphate guanylyltransferase ManC TR:Q9RCB1 (EMBL:AJ251712) (468 aa) fasta scores: E(): 0, 99.8% id in 468 aa, and to Yersinia enterocolitica mannose-1-phosphate guanylyltransferase RfbM or ManC TR:Q56874 (EMBL:U46859) (465 aa) fasta scores: E(): 0, 80.7% id in 462 aa, and identical to the previously sequenced Yersinia pestis mannose-1-phosphate guanylyltransferase ManC TR:Q9RCC5 (EMBL:AJ251713) (468 aa) fasta scores: E(): 0, 100.0% id in 468 aa; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
  
 0.609
ddhA
Similar to Yersinia pseudotuberculosis CDP-D-glucose-4,6-dehydratase AscB or DdhB TR:Q57329 (EMBL:L33181) (357 aa) fasta scores: E(): 0, 99.2% id in 358 aa, and to Yersinia enterocolitica CDP-glucose 4,6-dehydratase ddhb or RfbG TR:Q56861 (EMBL:U46859) (358 aa) fasta scores: E(): 0, 77.7% id in 359 aa. There is a frameshift following codon 41. The frameshift occurs within a Homopolymeric tract of 11C. The sequence has been checked and is believed to be correct.
  
 
 0.595
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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