STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hisFHistidine biosynthesic protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (258 aa)    
Predicted Functional Partners:
hisI
Similar to Escherichia coli histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase SW:HIS2_ECOLI (P06989) (203 aa) fasta scores: E(): 0, 79.8% id in 203 aa, and to Salmonella typhimurium histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase SW:HIS2_SALTY (P10367) (203 aa) fasta scores: E(): 0, 79.3% id in 203 aa; In the C-terminal section; belongs to the PRA-PH family.
  
 0.999
hisA
Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 0, 79.5% id in 244 aa, and to Salmonella typhimurium phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_SALTY (P10372) (246 aa) fasta scores: E(): 0, 76.0% id in 246 aa.
 
0.999
hisH
Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 0.999
hisB
Similar to Escherichia coli histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase HisB TR:Q9S5G5 (P06987) (355 aa) fasta scores: E(): 0, 81.4% id in 355 aa,and to Salmonella typhimurium histidine biosynthesis bifunctional protein HisB [includes: histidinol-phosphatase HisB SW:HIS7_SALTY (P10368) (354 aa) fasta scores: E(): 0,78.9% id in 355 aa.
 
 
 0.999
hisC
Similar to Escherichia coli histidinol-phosphate aminotransferase HisC SW:HIS8_ECOLI (P06986) (356 aa) fasta scores: E(): 0, 74.3% id in 346 aa, and to Salmonella typhimurium histidinol-phosphate aminotransferase HisC SW:HIS8_SALTY (P10369) (359 aa) fasta scores: E(): 0, 73.5% id in 358 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 
 0.999
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.998
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase; Similar to Escherichia coli bifunctional purine biosynthesis protein PurH SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 0, 87.1% id in 529 aa, and to Salmonella typhimurium bifunctional purine biosynthesis protein PurH SW:PUR9_SALTY (P26978) (508 aa) fasta scores: E(): 0, 86.8% id in 508 aa.
  
 
 0.955
purB
Similar to Escherichia coli adenylosuccinate lyase PurB SW:PUR8_ECOLI (P25739) (456 aa) fasta scores: E(): 0,88.6% id in 456 aa, and to Vibrio cholerae adenylosuccinate lyase Vc1126 TR:Q9KSY0 (EMBL:AE004193) (456 aa) fasta scores: E(): 0, 78.5% id in 456 aa.
  
 
  0.940
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
 
 0.936
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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