STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
b1062Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)    
Predicted Functional Partners:
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
 
 0.997
pyrB
Similar to Escherichia coli aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_ECOLI (P00479) (310 aa) fasta scores: E(): 0, 84.8% id in 310 aa,and to Erwinia herbicola aspartate transcarbamylase catalytic subunit PyrB TR:Q9RMS8 (EMBL:AF190426) (311 aa) fasta scores: E(): 0, 85.9% id in 311 aa.
   
 
 0.996
pyrI
Aspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase.
   
 
  0.985
b0033
Similar to Escherichia coli carbamoyl-phosphate synthase large chain CarB SW:CARB_ECOLI (P00968) (1072 aa) fasta scores: E(): 0, 92.6% id in 1072 aa, and to Salmonella typhimurium carbamoyl-phosphate synthase large chain CarB SW:CARB_SALTY (P14846) (1074 aa) fasta scores: E(): 0, 92.7% id in 1072 aa.
   
 
 0.924
b0032
Similar to Escherichia coli carbamoyl-phosphate synthase small chain CarA SW:CARA_ECOLI (P00907) (382 aa) fasta scores: E(): 0, 86.4% id in 381 aa, and to Salmonella typhimurium carbamoyl-phosphate synthase small chain CarA SW:CARA_SALTY (P14845) (382 aa) fasta scores: E(): 0, 86.4% id in 381 aa; Belongs to the CarA family.
   
  
 0.729
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.691
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
   
    0.642
guaA
Putative GMP synthase; Catalyzes the synthesis of GMP from XMP.
   
  
 0.622
nagD
Similar to Escherichia coli N-acetylglucosamine utilization operon hypothetical protein NagD SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 0, 86.0% id in 250 aa,and to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 0, 45.0% id in 249 aa.
    
   0.614
purI-2
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
   
  
 0.580
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.