STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fadDlong-chain-fatty-acid-CoA ligase; Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids; Belongs to the ATP-dependent AMP-binding enzyme family. (562 aa)    
Predicted Functional Partners:
irp1
Previously sequenced as Yersinia pestis yersiniabactin biosynthetic protein Irp1 TR:Q9Z373 (EMBL:AL031866) (3163 aa) fasta scores: E(): 0, 100.0% id in 3163 aa. Similar to Yersinia enterocolitica HMWP1 protein Irp1 TR:O54511 (EMBL:Y12527) (3161 aa) fasta scores: E(): 0, 97.9% id in 3163 aa.
  
 0.999
YPO0537
Putative AMP-binding enzyme-family protein; Similar to Rattus norvegicus long-chain-fatty-acid--CoA ligase FACL5 SW:LCFE_RAT (O88813) (683 aa) fasta scores: E(): 0, 29.7% id in 609 aa,and to Vibrio cholerae putative long-chain-fatty-acid--CoA ligase VC2484 TR:Q9KP89 (EMBL:AE004318) (601 aa) fasta scores: E(): 0, 56.7% id in 596 aa.
  
 
0.949
fadB
Fatty acid oxidation complex alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
 
 0.949
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
 
 
0.942
fadI-2
Putative 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
  
 
 0.922
YPO0776
Putative siderophore biosysnthesis protein; Similar to N-terminus of Yersinia pestis yersiniabactin biogenesis protein Irp2 TR:Q9Z399 (EMBL:AL031866) (2041 aa) fasta scores: E(): 0, 31.1% id in 1659 aa, and to Pseudomonas aeruginosa pyochelin synthetase PchF TR:Q9RFM7 (EMBL:AF184622) (1809 aa) fasta scores: E(): 0, 34.1% id in 1957 aa. and to Vibrio anguillarum anguibactin biosynthesis protein AngR SW:ANGR_VIBAN (P19828) (1048 aa) fasta scores: E(): 0, 32.1% id in 844 aa. CDS contains a glutamine and threonine rich imperfect repeat region, residues 996 to 1065.
 
0.912
fadA
3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity).
  
 
 0.905
irp2
Previously sequenced as Yersinia pestis yersiniabactin biosynthetic protein Irp2 TR:Q9Z399 (EMBL:AL031866) (2041 aa) fasta scores: E(): 0, 100.0% id in 2035 aa. Similar to Yersinia enterocolitica high-molecular-weight protein 2 Irp2 SW:HMP2_YEREN (P48633) (2035 aa) fasta scores: E(): 0, 98.6% id in 2035 aa. The previously sequenced Yersinia pestis Irp2 ORF starts at a valine situated 6 aa upstream from the methionine. However,the methionine start, has a good ribosome-binding site.
 
0.903
dadA
D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids.
   
  
 0.886
hisJ
Similar to Salmonella typhimurium histidine-binding periplasmic protein precursor HisJ SW:HISJ_SALTY (P02910) (260 aa) fasta scores: E(): 0, 76.4% id in 258 aa, and to Escherichia coli histidine-binding periplasmic protein precursor HisJ SW:HISJ_ECOLI (P39182) (260 aa) fasta scores: E(): 0, 76.4% id in 259 aa; Belongs to the bacterial solute-binding protein 3 family.
   
    0.885
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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