STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rluBPutative RNA pseudouridylate synthase-family protein; Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family. (318 aa)    
Predicted Functional Partners:
engA
Putative GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
 
  
 0.908
cmk
Cytidylate kinase; Similar to Escherichia coli cytidylate kinase Cmk SW:KCY_ECOLI (P23863) (227 aa) fasta scores: E(): 0, 84.5% id in 226 aa, and to Vibrio cholerae cytidylate kinase VC1916 TR:Q9KQT2 (EMBL:AE004267) (229 aa) fasta scores: E(): 0, 67.0% id in 224 aa.
  
 0.862
xth
Similar to Escherichia coli exodeoxyribonuclease III XthA SW:EX3_ECOLI (P09030) (268 aa) fasta scores: E(): 0,80.1% id in 266 aa, and to Salmonella typhimurium exodeoxyribonuclease III XthA SW:EX3_SALTY (Q9Z612) (268 aa) fasta scores: E(): 0, 78.6% id in 266 aa.
  
    0.832
rlmL
Conserved hypothetical protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family.
  
 
 0.778
rbaB
ATP-dependent RNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily.
  
 
 0.659
rlmN
Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.
 
  
 0.572
rluC
Ribosomal large subunit pseudouridine synthase C; Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RluA family.
 
 
 0.546
YPO4065
Similar to Escherichia coli hypothetical protein YibL SW:YIBL_ECOLI (P36564) (120 aa) fasta scores: E(): 2.9e-21, 61.2% id in 116 aa, and to the C-terminus of Vibrio cholerae hypothetical protein VCA0010 TR:Q9KNF4 (EMBL:AE004344) (145 aa) fasta scores: E(): 5.7e-10, 33.1% id in 118 aa.
    
 
 0.538
rppH
Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily.
   
 
 0.507
trmB
Putative methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
 
  
 0.489
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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