STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fadI-2Putative 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa)    
Predicted Functional Partners:
faoA
Putative fatty oxidation complex alpha subunit,enoyl-CoA hydratase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
 0.999
fadB
Fatty acid oxidation complex alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
 0.999
yafH
Probable acyl-CoA dehydrogenase; Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for the utilization of medium- and long- chain fatty acids as sole carbon sources for growth.
 
 0.998
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 
 0.994
YPO1458
Similar to Homo sapiens mitochondria enoyl-CoA hydratase ECHS1 SW:ECHM_HUMAN (P30084) (290 aa) fasta scores: E(): 1.2e-07, 27.8% id in 198 aa, and to Amycolatopsis orientalis putative vancomycin biosynthesis protein PCZA361.9 TR:O52797 (EMBL:AJ223998) (267 aa) fasta scores: E(): 1.8e-08, 27.2% id in 235 aa.
 
 0.990
YPO1459
Putative enoyl-CoA hydratase; Similar to an internal region of Rattus norvegicus mitochondrial enoyl-CoA hydratase ECHS1 SW:ECHM_RAT (P14604) (290 aa) fasta scores: E(): 1.5e-13, 25.2% id in 238 aa, and to Bacillus subtilis putative polyketide biosynthesis enoyl-CoA hydratase homolog PksI SW:PKSI_BACSU (P40802) (249 aa) fasta scores: E(): 7.3e-24, 33.5% id in 248 aa.
 
 0.988
YPO1457
Similar to Streptococcus pneumoniae HMG-CoA synthase MvaS TR:AAG02453 (EMBL:AF290098) (398 aa) fasta scores: E(): 1.7e-22, 33.8% id in 391 aa, and to Myxococcus xanthus polyketide antibiotic TA post-modification protein Tac TR:Q9XB06 (EMBL:AJ132503) (420 aa) fasta scores: E(): 2.1e-31, 34.0% id in 424 aa.
  
 0.986
fadA
3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity).
  
 
 
0.985
gltA
Citrate synthase GltA; Similar to Escherichia coli citrate synthase GltA SW:CISY_ECOLI (P00891) (427 aa) fasta scores: E(): 0, 86.7% id in 427 aa, and to Vibrio cholerae citrate synthase VC2092 TR:Q9KQA8 (EMBL:AE004283) (431 aa) fasta scores: E(): 0, 78.0% id in 422 aa.
  
 0.973
aceB
Similar to Escherichia coli malate synthase A AceB or Mas SW:MASY_ECOLI (P08997) (533 aa) fasta scores: E(): 0, 79.5% id in 533 aa, and to Vibrio cholerae malate synthase Vc0734 TR:Q9KTZ6 (EMBL:AE004159) (556 aa) fasta scores: E(): 0, 71.4% id in 524 aa.
   
 
 0.971
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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