STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
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[Homology]
Score
purI-2Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1296 aa)    
Predicted Functional Partners:
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 0.999
purI
Putative phosphoribosylaminoimidazole synthetase; Similar to Salmonella typhimurium probable 5'-phosphoribosyl-5-aminoimidazole synthetase PurI TR:P74883 (EMBL:U68765) (345 aa) fasta scores: E(): 0,83.5% id in 345 aa, and to Escherichia coli probable phosphoribosylaminoimidazole synthetase PurM TR:AAG14577 (EMBL:AF293164) (350 aa) fasta scores: E(): 0, 82.6% id in 345 aa.
 
 
 0.999
purN
Putative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.999
purC
Similar to Escherichia coli phosphoribosylaminoimidazole-succinocarboxamide synthase PurC SW:PUR7_ECOLI (P21155) (237 aa) fasta scores: E(): 0,86.9% id in 237 aa, and to Pseudomonas aeruginosa phosphoribosylaminoimidazole-succinocarboxamide synthase Purc or Pa1013 TR:AAG04402 (EMBL:AE004533) (236 aa) fasta scores: E(): 0, 72.5% id in 236 aa; Belongs to the SAICAR synthetase family.
  
 0.999
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
  
 0.999
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
  
 0.999
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase; Similar to Escherichia coli bifunctional purine biosynthesis protein PurH SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 0, 87.1% id in 529 aa, and to Salmonella typhimurium bifunctional purine biosynthesis protein PurH SW:PUR9_SALTY (P26978) (508 aa) fasta scores: E(): 0, 86.8% id in 508 aa.
  
 
 0.999
purD
Similar to Escherichia coli phosphoribosylamine--glycine ligase PurD SW:PUR2_ECOLI (P15640) (429 aa) fasta scores: E(): 0, 80.8% id in 426 aa,and to Salmonella typhimurium phosphoribosylamine--glycine ligase PurD or Stmf1.31 SW:PUR2_SALTY (P26977) (429 aa) fasta scores: E(): 0, 79.6% id in 426 aa.
 
 0.999
purT
Phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
  
 
 0.998
purB
Similar to Escherichia coli adenylosuccinate lyase PurB SW:PUR8_ECOLI (P25739) (456 aa) fasta scores: E(): 0,88.6% id in 456 aa, and to Vibrio cholerae adenylosuccinate lyase Vc1126 TR:Q9KSY0 (EMBL:AE004193) (456 aa) fasta scores: E(): 0, 78.5% id in 456 aa.
  
  
 0.993
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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