STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (212 aa)    
Predicted Functional Partners:
msrB
Similar to Escherichia coli hypothetical protein YeaA SW:YEAA_ECOLI (P39903) (137 aa) fasta scores: E(): 0,69.3% id in 137 aa, and to Pasteurella multocida hypothetical protein PM0923 TR:AAK03007 (EMBL:AE006131) (130 aa) fasta scores: E(): 4.1e-32, 57.1% id in 126 aa; Belongs to the MsrB Met sulfoxide reductase family.
 
 0.997
ccmG
Thiol:disulfide interchange protein DsbE; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily.
  
 0.984
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.897
cycZ
Thiol:disulfide interchange protein; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.
   
 
 0.876
YPO3916
Similar to Vibrio cholerae peroxiredoxin family protein/glutaredoxin VC2637 TR:Q9KNU3 (EMBL:AE004330) (247 aa) fasta scores: E(): 0, 81.3% id in 241 aa, and to Haemophilus influenzae hypothetical protein HI0572 SW:Y572_HAEIN (P44758) (241 aa) fasta scores: E(): 0, 80.3% id in 239 aa. C-terminal region is similar to YPO0066 (50.0% identity in 66 aa overlap).
  
 
 0.828
grxC
Glutaredoxin; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
  
 
 0.781
grxA
Glutaredoxin 1; Similar to Salmonella typhimurium glutaredoxin 1 GrxA SW:GRX1_SALTY (Q9Z5Z3) (87 aa) fasta scores: E(): 2.1e-29, 79.1% id in 86 aa, and to Escherichia coli glutaredoxin 1 GrxA or grX SW:GLR1_ECOLI (P00277) (85 aa) fasta scores: E(): 1.6e-23, 69.9% id in 83 aa.
  
 
 0.780
nrdH
Putative glutaredoxin; Similar to Corynebacterium ammoniagenes NrdH-redoxin NrdH TR:O69271 (EMBL:Y09572) (75 aa) fasta scores: E(): 4.4e-14, 49.3% id in 75 aa, and to Mycobacterium tuberculosis hypothetical protein RV3053C TR:P95106 (EMBL:Z83866) (79 aa) fasta scores: E(): 2.9e-17, 54.7% id in 75 aa.
  
 
 0.779
flgK
Similar to Escherichia coli flagellar hook-associated protein 1 FlgK SW:FLGK_ECOLI (P33235) (546 aa) fasta scores: E(): 6.8e-24, 26.6% id in 477 aa, and to Salmonella typhimurium flagellar hook-associated protein 1 FlgK SW:FLGK_SALTY (P15932) (552 aa) fasta scores: E(): 1.4e-23, 25.9% id in 552 aa.
   
   0.696
flaS
Similar to Salmonella typhimurium flagellar hook-associated protein 1 FlgK or FlaS or FlaW SW:FLGK_SALTY (P15932) (552 aa) fasta scores: E(): 0, 56.3% id in 558 aa, and to Escherichia coli flagellar hook-associated protein 1 FlgK or FlaS or FlaW SW:FLGK_ECOLI (P33235) (546 aa) fasta scores: E(): 0, 57.8% id in 552 aa.
    
   0.694
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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