STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceKAcetate operon repressor (pseudogene); Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (575 aa)    
Predicted Functional Partners:
aceA
Isocitrate lyase; Similar to Escherichia coli isocitrate lyase AceA or Icl SW:ACEA_ECOLI (P05313) (434 aa) fasta scores: E(): 0,85.2% id in 432 aa, and to Vibrio cholerae isocitrate lyase Vc0736 TR:Q9KTZ4 (EMBL:AE004159) (437 aa) fasta scores: E(): 0, 76.8% id in 436 aa.
 
  
 0.969
icd
Similar to Escherichia coli isocitrate dehydrogenase [NADP] SW:IDH_ECOLI (P08200) (416 aa) fasta scores: E(): 0,90.2% id in 417 aa, and to Salmonella enterica I isocitrate dehydrogenase Icd TR:O30811 (EMBL:AF017605) (388 aa) fasta scores: E(): 0, 92.7% id in 386 aa.
 
 
 0.943
aceB
Similar to Escherichia coli malate synthase A AceB or Mas SW:MASY_ECOLI (P08997) (533 aa) fasta scores: E(): 0, 79.5% id in 533 aa, and to Vibrio cholerae malate synthase Vc0734 TR:Q9KTZ6 (EMBL:AE004159) (556 aa) fasta scores: E(): 0, 71.4% id in 524 aa.
  
  
 0.773
mglC
Similar to Escherichia coli galactoside transport system permease protein MglC SW:MGLC_ECOLI (P23200) (336 aa) fasta scores: E(): 0, 89.3% id in 336 aa, and to Vibrio cholerae galactoside ABC transporter, permease protein vc1328 TR:Q9KSD0 (EMBL:AE004212) (337 aa) fasta scores: E(): 0, 81.3% id in 327 aa.
   
  
 0.571
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.