STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
coaAPantothenate kinase; Similar to Escherichia coli pantothenate kinase CoaA or Rts or PanK SW:COAA_ECOLI (P15044) (316 aa) fasta scores: E(): 0, 85.8% id in 316 aa, and to Salmonella typhimurium pantothenate kinase CoaA SW:COAA_SALTY (Q9L9K3) (316 aa) fasta scores: E(): 0, 85.8% id in 316 aa. (316 aa)    
Predicted Functional Partners:
dfp
DNA/pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
   
 
 0.978
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
   
 
 0.975
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
   
 
 0.965
acpH
Conserved hypothetical protein; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family.
   
 
 0.939
YPO3378
Similar to Escherichia coli hypothetical protein MazG SW:MAZG_ECOLI (P33646) (263 aa) fasta scores: E(): 0,72.6% id in 266 aa, and to Vibrio cholerae MazG protein VC2450 TR:Q9KPC2 (EMBL:AE004315) (278 aa) fasta scores: E(): 0, 56.0% id in 268 aa.
   
 
  0.933
coaE
Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.661
bioR
Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
  
  
 0.528
yhhK
Putative acetyltransferase; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion; Belongs to the PanZ/PanM family.
      
 0.518
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
  
 
  0.485
YPO3757
Similar to Pseudomonas syringae acetyltransferase Ttr SW:TTR_PSESY (P16966) (177 aa) fasta scores: E(): 2.5e-29, 47.6% id in 166 aa, and to Streptomyces coelicolor putative acetyltransferase Sc1a2.12 TR:Q9L229 (EMBL:AL138598) (181 aa) fasta scores: E(): 2e-21, 40.9% id in 164 aa.
       0.475
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.