node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DFR1 | Q5KAU8_CRYNJ | Q07801 | Q5KAU8 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.992 |
DFR1 | Q5KCY2_CRYNJ | Q07801 | Q5KCY2 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Dihydrofolate synthase, putative. | 0.988 |
DFR1 | Q5KEG6_CRYNJ | Q07801 | Q5KEG6 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Folic acid and derivative metabolism-related protein, putative. | 0.983 |
DFR1 | Q5KGC2_CRYNJ | Q07801 | Q5KGC2 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Methionyl-tRNA formyltransferase, putative. | 0.979 |
DFR1 | Q5KJH4_CRYNJ | Q07801 | Q5KJH4 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | FSH1 domain-containing protein. | 0.958 |
DFR1 | Q5KJZ3_CRYNJ | Q07801 | Q5KJZ3 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.988 |
DFR1 | Q5KK40_CRYNJ | Q07801 | Q5KK40 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.986 |
DFR1 | Q5KK61_CRYNJ | Q07801 | Q5KK61 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase, putative. | 0.961 |
DFR1 | Q5KNE3_CRYNJ | Q07801 | Q5KNE3 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Purine nucleotide biosynthesis-related protein, putative. | 0.962 |
DFR1 | TMP1 | Q07801 | P0CS12 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Thymidylate synthase. | 0.999 |
Q5KAU8_CRYNJ | DFR1 | Q5KAU8 | Q07801 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | 0.992 |
Q5KAU8_CRYNJ | Q5KCY2_CRYNJ | Q5KAU8 | Q5KCY2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Dihydrofolate synthase, putative. | 0.780 |
Q5KAU8_CRYNJ | Q5KEG6_CRYNJ | Q5KAU8 | Q5KEG6 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Folic acid and derivative metabolism-related protein, putative. | 0.992 |
Q5KAU8_CRYNJ | Q5KGC2_CRYNJ | Q5KAU8 | Q5KGC2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Methionyl-tRNA formyltransferase, putative. | 0.967 |
Q5KAU8_CRYNJ | Q5KJH4_CRYNJ | Q5KAU8 | Q5KJH4 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | FSH1 domain-containing protein. | 0.870 |
Q5KAU8_CRYNJ | Q5KJZ3_CRYNJ | Q5KAU8 | Q5KJZ3 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.781 |
Q5KAU8_CRYNJ | Q5KK40_CRYNJ | Q5KAU8 | Q5KK40 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.998 |
Q5KAU8_CRYNJ | Q5KK61_CRYNJ | Q5KAU8 | Q5KK61 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Phosphoribosylglycinamide formyltransferase, putative. | 0.992 |
Q5KAU8_CRYNJ | Q5KNE3_CRYNJ | Q5KAU8 | Q5KNE3 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Purine nucleotide biosynthesis-related protein, putative. | 0.978 |
Q5KAU8_CRYNJ | TMP1 | Q5KAU8 | P0CS12 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | Thymidylate synthase. | 0.983 |