STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DFR1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. (229 aa)    
Predicted Functional Partners:
TMP1
Thymidylate synthase.
 
 0.999
Q5KAU8_CRYNJ
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
 
 0.992
Q5KCY2_CRYNJ
Dihydrofolate synthase, putative.
     
 0.988
Q5KJZ3_CRYNJ
Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.
     
 0.988
Q5KK40_CRYNJ
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.
    
 0.986
Q5KEG6_CRYNJ
Folic acid and derivative metabolism-related protein, putative.
  
 
 0.983
Q5KGC2_CRYNJ
Methionyl-tRNA formyltransferase, putative.
  
 
 0.979
Q5KNE3_CRYNJ
Purine nucleotide biosynthesis-related protein, putative.
  
 0.962
Q5KK61_CRYNJ
Phosphoribosylglycinamide formyltransferase, putative.
  
 
 0.961
Q5KJH4_CRYNJ
FSH1 domain-containing protein.
 
 
 0.958
Your Current Organism:
Cryptococcus neoformans
NCBI taxonomy Id: 214684
Other names: C. neoformans var. neoformans JEC21, Cryptococcus neoformans JEC21, Cryptococcus neoformans var. neoformans JEC21, Cryptococcus neoformans var. neoformans serotype D JEC21, Cryptococcus neoformans var. neoformans strain JEC21, Filobasidiella neoformans var. neoformans strain JEC21
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