STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HOG1Mitogen-activated protein kinase HOG1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Also involved in response UV radiations and mediates the sensitivity to fludioxonil, an agricultural fungicide. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. (365 aa)    
Predicted Functional Partners:
Q5KN75_CRYNJ
MAP kinase kinase, putative.
  
0.990
Q5KLD2_CRYNJ
BZip transcription factor, putative.
   
 0.984
Q5KNY9_CRYNJ
Ptc1p, putative.
   
 0.959
Q5K8S3_CRYNJ
Protein-tyrosine-phosphatase, putative.
    
 0.957
Q5KK29_CRYNJ
Protein arginine N-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily.
   
 
  0.900
BRO1
Vacuolar protein-sorting protein BRO1; Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles; Belongs to the BRO1 family.
   
 0.814
RIM101
pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid- expressed genes (By similarity); Belongs to the pacC/RIM101 family.
   
 0.800
Q5KE48_CRYNJ
Transcription factor, putative.
    
 0.799
RAS1
Ras-like protein; Belongs to the small GTPase superfamily. Ras family.
   
 0.765
Q5KPY0_CRYNJ
Serine/threonine-protein kinase, putative.
  
 
0.734
Your Current Organism:
Cryptococcus neoformans
NCBI taxonomy Id: 214684
Other names: C. neoformans var. neoformans JEC21, Cryptococcus neoformans JEC21, Cryptococcus neoformans var. neoformans JEC21, Cryptococcus neoformans var. neoformans serotype D JEC21, Cryptococcus neoformans var. neoformans strain JEC21, Filobasidiella neoformans var. neoformans strain JEC21
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