STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sigHAlternative RNA polymerase sigma-E factor (sigma- 24) SigH (RpoE); Alternative sigma factor that plays a role in the oxidative-stress response (regulation of thioredoxin recycling). the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. this sigma factor is involved in heat shock and oxidative stress response; it is believed to control protein processing in the extracytoplasmic compartment. regulates positively DnaK and ClpB genes. regulates TrxB2, TrxC, and SigB genes. SigH may mediate the transcriptio [...] (255 aa)    
Predicted Functional Partners:
MMAR_1335
Binds sigma factor and inhibits it. probably involved in survival following heat shock and oxidative stress.
  
 
 0.991
rpoB
DNA-directed RNA polymerase, beta subunit, RpoB; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.986
rpoC
DNA-directed RNA polymerase, beta chain, RpoC; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.986
sigC
RNA polymerase sigma factor, SigC; Involved in promoter recognition, transcription initiation; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.891
sigF
The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. thought to be involved in survival and proliferation in lung granulomas during infection. thought to be involved in virulence and persistence processes. modulates expression of the 16 kDa alpha-crystallin homologue. negatively regulated by RsbW/UsfX.
  
  
 0.888
rpoA
DNA-directed RNA polymerase (alpha chain), RpoA; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 
 0.828
rpoZ
DNA-directed RNA polymerase (omega chain) RpoZ; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 
 0.805
sigD
Alternative RNA polymerase sigma-D factor, SigD; The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.772
MMAR_3276
The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.768
MMAR_1333
Iron-regulated short-chain dehydrogenase/reductase; Function unknown, probably involved in cellular metabolism.
  
  
 0.752
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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