node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMAR_2159 | MMAR_3978 | MMAR_2159 | MMAR_3978 | Conserved hypothetical protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | Coenzyme F420-dependent oxidoreductase. | 0.724 |
MMAR_2159 | fbiA | MMAR_2159 | MMAR_1281 | Conserved hypothetical protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | F420 biosynthesis protein FbiA; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.843 |
MMAR_2159 | fbiB | MMAR_2159 | MMAR_1280 | Conserved hypothetical protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | F420 biosynthesis protein FbiB; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | 0.791 |
MMAR_2159 | fbiC | MMAR_2159 | MMAR_4279 | Conserved hypothetical protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | F420 biosynthesis protein FbiC; Essential for coenzyme F420 production: participates in a portion of the F420 biosynthetic pathway between pyrimidinedione and fo (biosynthesis intermediate), before the deazaflavin ring is formed. | 0.665 |
MMAR_2159 | fbiD | MMAR_2159 | MMAR_1731 | Conserved hypothetical protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | Conserved hypothetical alanine rich membrane protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. | 0.737 |
MMAR_2159 | fgd1 | MMAR_2159 | MMAR_0709 | Conserved hypothetical protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | F420-dependent glucose-6-phosphate dehydrogenase Fgd1; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | 0.792 |
MMAR_2373 | MMAR_3978 | MMAR_2373 | MMAR_3978 | Conserved protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | Coenzyme F420-dependent oxidoreductase. | 0.733 |
MMAR_2373 | fbiA | MMAR_2373 | MMAR_1281 | Conserved protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | F420 biosynthesis protein FbiA; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.789 |
MMAR_2373 | fbiB | MMAR_2373 | MMAR_1280 | Conserved protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | F420 biosynthesis protein FbiB; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | 0.759 |
MMAR_2373 | fbiC | MMAR_2373 | MMAR_4279 | Conserved protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | F420 biosynthesis protein FbiC; Essential for coenzyme F420 production: participates in a portion of the F420 biosynthetic pathway between pyrimidinedione and fo (biosynthesis intermediate), before the deazaflavin ring is formed. | 0.550 |
MMAR_2373 | fbiD | MMAR_2373 | MMAR_1731 | Conserved protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | Conserved hypothetical alanine rich membrane protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. | 0.746 |
MMAR_2373 | fgd1 | MMAR_2373 | MMAR_0709 | Conserved protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | F420-dependent glucose-6-phosphate dehydrogenase Fgd1; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | 0.900 |
MMAR_3978 | MMAR_2159 | MMAR_3978 | MMAR_2159 | Coenzyme F420-dependent oxidoreductase. | Conserved hypothetical protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | 0.724 |
MMAR_3978 | MMAR_2373 | MMAR_3978 | MMAR_2373 | Coenzyme F420-dependent oxidoreductase. | Conserved protein; Function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins. | 0.733 |
MMAR_3978 | MMAR_4178 | MMAR_3978 | MMAR_4178 | Coenzyme F420-dependent oxidoreductase. | Conserved hypothetical protein. | 0.673 |
MMAR_3978 | MMAR_5035 | MMAR_3978 | MMAR_5035 | Coenzyme F420-dependent oxidoreductase. | Conserved hypothetical protein; Function unknown; contains a FMN-binding split barrel domain. possible role in the electron-transfer pathway. the FMN-binding split barrel is related to the ferredoxin reductase-like FAD-binding domain. flavodoxins are an example of a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential. | 0.706 |
MMAR_3978 | fbiA | MMAR_3978 | MMAR_1281 | Coenzyme F420-dependent oxidoreductase. | F420 biosynthesis protein FbiA; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.790 |
MMAR_3978 | fbiB | MMAR_3978 | MMAR_1280 | Coenzyme F420-dependent oxidoreductase. | F420 biosynthesis protein FbiB; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | 0.803 |
MMAR_3978 | fbiC | MMAR_3978 | MMAR_4279 | Coenzyme F420-dependent oxidoreductase. | F420 biosynthesis protein FbiC; Essential for coenzyme F420 production: participates in a portion of the F420 biosynthetic pathway between pyrimidinedione and fo (biosynthesis intermediate), before the deazaflavin ring is formed. | 0.567 |
MMAR_3978 | fbiD | MMAR_3978 | MMAR_1731 | Coenzyme F420-dependent oxidoreductase. | Conserved hypothetical alanine rich membrane protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. | 0.775 |