node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMAR_2773 | MMAR_4555 | MMAR_2773 | MMAR_4555 | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. | Conserved hypothetical protein. | 0.945 |
MMAR_2773 | aroA | MMAR_2773 | MMAR_1320 | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.677 |
MMAR_2773 | aroE | MMAR_2773 | MMAR_2173 | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. | Shikimate 5-dehydrogenase AroE; Possibly involved at the fourth step in the biosynthesis of chorismate within the biosynthesis of aromatic amino acids (the shikimate pathway) [catalytic activity: shikimate + NADP(+) = 5-dehydroshikimate + NADPH]; Belongs to the shikimate dehydrogenase family. | 0.441 |
MMAR_2773 | aroF | MMAR_2773 | MMAR_2175 | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. | Chorismate synthase AroF; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.963 |
MMAR_2773 | aroK | MMAR_2773 | MMAR_2176 | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.488 |
MMAR_2773 | mbtI | MMAR_2773 | MMAR_3706 | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. | Isochorismate synthase MbtI; Involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. possibly plays a role in the conversion of chorismate to salicilate (the starter unit for mycobactin siderophore construction). | 0.841 |
MMAR_2773 | trpE | MMAR_2773 | MMAR_2411 | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. | Anthranilate synthase component I TrpE; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high con [...] | 0.914 |
MMAR_3408 | aroF | MMAR_3408 | MMAR_2175 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Function unknown; probably involved in cellular metabolism. | Chorismate synthase AroF; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.974 |
MMAR_4555 | MMAR_2773 | MMAR_4555 | MMAR_2773 | Conserved hypothetical protein. | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. | 0.945 |
MMAR_4555 | aroA | MMAR_4555 | MMAR_1320 | Conserved hypothetical protein. | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.677 |
MMAR_4555 | aroE | MMAR_4555 | MMAR_2173 | Conserved hypothetical protein. | Shikimate 5-dehydrogenase AroE; Possibly involved at the fourth step in the biosynthesis of chorismate within the biosynthesis of aromatic amino acids (the shikimate pathway) [catalytic activity: shikimate + NADP(+) = 5-dehydroshikimate + NADPH]; Belongs to the shikimate dehydrogenase family. | 0.441 |
MMAR_4555 | aroF | MMAR_4555 | MMAR_2175 | Conserved hypothetical protein. | Chorismate synthase AroF; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.963 |
MMAR_4555 | aroK | MMAR_4555 | MMAR_2176 | Conserved hypothetical protein. | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.548 |
MMAR_4555 | mbtI | MMAR_4555 | MMAR_3706 | Conserved hypothetical protein. | Isochorismate synthase MbtI; Involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. possibly plays a role in the conversion of chorismate to salicilate (the starter unit for mycobactin siderophore construction). | 0.862 |
MMAR_4555 | trpE | MMAR_4555 | MMAR_2411 | Conserved hypothetical protein. | Anthranilate synthase component I TrpE; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high con [...] | 0.949 |
aroA | MMAR_2773 | MMAR_1320 | MMAR_2773 | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. | 0.677 |
aroA | MMAR_4555 | MMAR_1320 | MMAR_4555 | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Conserved hypothetical protein. | 0.677 |
aroA | aroB | MMAR_1320 | MMAR_2177 | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.980 |
aroA | aroB_2 | MMAR_1320 | MMAR_2329 | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate synthase AroB_2; Involved at the second step in the biosynthesis of chorismate within the biosynthesis of aromatic amino acids (the shikimate pathway) [catalytic activity: 7-phospho-3- deoxy-arabino-heptulosonate = 3-dehydroquinate + orthophosphate]. | 0.977 |
aroA | aroE | MMAR_1320 | MMAR_2173 | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate 5-dehydrogenase AroE; Possibly involved at the fourth step in the biosynthesis of chorismate within the biosynthesis of aromatic amino acids (the shikimate pathway) [catalytic activity: shikimate + NADP(+) = 5-dehydroshikimate + NADPH]; Belongs to the shikimate dehydrogenase family. | 0.993 |