STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrRPyrimidine operon regulatory protein PyrR; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. (187 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase PyrB; Involved in pyrimidine biosynthesis (second step) [catalytic activity : carbamoyl phosphate + l-aspartate = phosphate + N-carbamoyl-L-aspartate]; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 
 0.998
pyrC
Dihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 
 0.996
pyrF
Orotidine 5'-phosphate decarboxylase PyrF; Involved in the biosynthesis of pyrimidines [catalytic activity : orotidine 5'-phosphate = ump + CO(2)]; Belongs to the OMP decarboxylase family. Type 2 subfamily.
  
 
 0.996
carB
Carbamoyl-phosphate synthase large chain CarB; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.]; Belongs to the CarB family.
 
  
 0.975
upp
Uracil phosphoribosyltransferase Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
     
 0.974
carA
Carbamoyl-phosphate synthase small chain CarA; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate]; Belongs to the CarA family.
  
  
 0.971
MMAR_2197
Secreted protein.
  
  
 0.955
pyrH
Uridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP.
 
  
 0.937
deoA
Thymidine phosphorylase DeoA; The enzymes which catalyze the reversible phosphorylosis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [catalytic activity: thymidine + phosphate = thymine + 2-deoxy-D- ribose 1-phosphate].
    
 0.914
MMAR_4949
Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices.
  
  
 0.908
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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