node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMAR_2197 | MMAR_4949 | MMAR_2197 | MMAR_4949 | Secreted protein. | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | 0.765 |
MMAR_2197 | carA | MMAR_2197 | MMAR_2198 | Secreted protein. | Carbamoyl-phosphate synthase small chain CarA; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate]; Belongs to the CarA family. | 0.967 |
MMAR_2197 | carB | MMAR_2197 | MMAR_2199 | Secreted protein. | Carbamoyl-phosphate synthase large chain CarB; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.]; Belongs to the CarB family. | 0.990 |
MMAR_2197 | pyrB | MMAR_2197 | MMAR_2195 | Secreted protein. | Aspartate carbamoyltransferase PyrB; Involved in pyrimidine biosynthesis (second step) [catalytic activity : carbamoyl phosphate + l-aspartate = phosphate + N-carbamoyl-L-aspartate]; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.970 |
MMAR_2197 | pyrC | MMAR_2197 | MMAR_2196 | Secreted protein. | Dihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.971 |
MMAR_2197 | pyrF | MMAR_2197 | MMAR_2200 | Secreted protein. | Orotidine 5'-phosphate decarboxylase PyrF; Involved in the biosynthesis of pyrimidines [catalytic activity : orotidine 5'-phosphate = ump + CO(2)]; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.963 |
MMAR_2197 | pyrR | MMAR_2197 | MMAR_2194 | Secreted protein. | Pyrimidine operon regulatory protein PyrR; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. | 0.955 |
MMAR_2197 | upp | MMAR_2197 | MMAR_1217 | Secreted protein. | Uracil phosphoribosyltransferase Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.458 |
MMAR_4949 | MMAR_2197 | MMAR_4949 | MMAR_2197 | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | Secreted protein. | 0.765 |
MMAR_4949 | carA | MMAR_4949 | MMAR_2198 | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | Carbamoyl-phosphate synthase small chain CarA; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate]; Belongs to the CarA family. | 0.810 |
MMAR_4949 | carB | MMAR_4949 | MMAR_2199 | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | Carbamoyl-phosphate synthase large chain CarB; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.]; Belongs to the CarB family. | 0.808 |
MMAR_4949 | pyrB | MMAR_4949 | MMAR_2195 | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | Aspartate carbamoyltransferase PyrB; Involved in pyrimidine biosynthesis (second step) [catalytic activity : carbamoyl phosphate + l-aspartate = phosphate + N-carbamoyl-L-aspartate]; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.911 |
MMAR_4949 | pyrC | MMAR_4949 | MMAR_2196 | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | Dihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.917 |
MMAR_4949 | pyrF | MMAR_4949 | MMAR_2200 | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | Orotidine 5'-phosphate decarboxylase PyrF; Involved in the biosynthesis of pyrimidines [catalytic activity : orotidine 5'-phosphate = ump + CO(2)]; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.827 |
MMAR_4949 | pyrR | MMAR_4949 | MMAR_2194 | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | Pyrimidine operon regulatory protein PyrR; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. | 0.908 |
MMAR_4949 | upp | MMAR_4949 | MMAR_1217 | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | Uracil phosphoribosyltransferase Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.605 |
carA | MMAR_2197 | MMAR_2198 | MMAR_2197 | Carbamoyl-phosphate synthase small chain CarA; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate]; Belongs to the CarA family. | Secreted protein. | 0.967 |
carA | MMAR_4949 | MMAR_2198 | MMAR_4949 | Carbamoyl-phosphate synthase small chain CarA; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate]; Belongs to the CarA family. | Permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices. | 0.810 |
carA | carB | MMAR_2198 | MMAR_2199 | Carbamoyl-phosphate synthase small chain CarA; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate]; Belongs to the CarA family. | Carbamoyl-phosphate synthase large chain CarB; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.]; Belongs to the CarB family. | 0.999 |
carA | pyrB | MMAR_2198 | MMAR_2195 | Carbamoyl-phosphate synthase small chain CarA; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate]; Belongs to the CarA family. | Aspartate carbamoyltransferase PyrB; Involved in pyrimidine biosynthesis (second step) [catalytic activity : carbamoyl phosphate + l-aspartate = phosphate + N-carbamoyl-L-aspartate]; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |