node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aceAb | acs | MMAR_2821 | MMAR_5155 | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.434 |
aceAb | acs_1 | MMAR_2821 | MMAR_3488 | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | Activates acetate to acetyl-coenzyme A [catalytic activity: ATP + acetate + CoA = AMP + pyrophosphate + acetyl-CoA]. | 0.434 |
aceAb | citA | MMAR_2821 | MMAR_4643 | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | Citrate synthase II CitA; Involved in tricarboxylic acid cycle (krebs cycle) [catalytic activity: citrate + CoA = acetyl-CoA + H2O + oxaloacetate]; Belongs to the citrate synthase family. | 0.583 |
aceAb | glcB | MMAR_2821 | MMAR_2713 | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | Malate synthase G GlcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.988 |
aceAb | gltA1 | MMAR_2821 | MMAR_1381 | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | Citrate synthase I GltA1; Involved in tricarboxylic acid cycle (krebs cycle) [catalytic activity: citrate + CoA = acetyl-CoA + H2O + oxaloacetate]; Belongs to the citrate synthase family. | 0.501 |
aceAb | gltA2 | MMAR_2821 | MMAR_4640 | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | Citrate synthase I GltA2; Involved in tricarboxylic acid cycle (krebs cycle) [catalytic activity: citrate + CoA = acetyl-CoA + H2O + oxaloacetate]; Belongs to the citrate synthase family. | 0.540 |
aceAb | icl | MMAR_2821 | MMAR_0792 | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | Isocitrate lyase Icl; Involved in glyoxylate bypass (at the first step), an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi) [catalytic activity: isocitrate = succinate + glyoxylate]. involved in the persistence in the host. | 0.919 |
aceAb | pta | MMAR_2821 | MMAR_0710 | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | Phosphate acetyltransferase Pta; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.738 |
acs | aceAb | MMAR_5155 | MMAR_2821 | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | 0.434 |
acs | acs_1 | MMAR_5155 | MMAR_3488 | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Activates acetate to acetyl-coenzyme A [catalytic activity: ATP + acetate + CoA = AMP + pyrophosphate + acetyl-CoA]. | 0.917 |
acs | citA | MMAR_5155 | MMAR_4643 | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Citrate synthase II CitA; Involved in tricarboxylic acid cycle (krebs cycle) [catalytic activity: citrate + CoA = acetyl-CoA + H2O + oxaloacetate]; Belongs to the citrate synthase family. | 0.962 |
acs | glcB | MMAR_5155 | MMAR_2713 | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Malate synthase G GlcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.963 |
acs | gltA1 | MMAR_5155 | MMAR_1381 | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Citrate synthase I GltA1; Involved in tricarboxylic acid cycle (krebs cycle) [catalytic activity: citrate + CoA = acetyl-CoA + H2O + oxaloacetate]; Belongs to the citrate synthase family. | 0.966 |
acs | gltA2 | MMAR_5155 | MMAR_4640 | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Citrate synthase I GltA2; Involved in tricarboxylic acid cycle (krebs cycle) [catalytic activity: citrate + CoA = acetyl-CoA + H2O + oxaloacetate]; Belongs to the citrate synthase family. | 0.966 |
acs | icl | MMAR_5155 | MMAR_0792 | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Isocitrate lyase Icl; Involved in glyoxylate bypass (at the first step), an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi) [catalytic activity: isocitrate = succinate + glyoxylate]. involved in the persistence in the host. | 0.562 |
acs | pta | MMAR_5155 | MMAR_0710 | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Phosphate acetyltransferase Pta; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.952 |
acs_1 | aceAb | MMAR_3488 | MMAR_2821 | Activates acetate to acetyl-coenzyme A [catalytic activity: ATP + acetate + CoA = AMP + pyrophosphate + acetyl-CoA]. | Isocitrate lyase AceAb; Involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]. | 0.434 |
acs_1 | acs | MMAR_3488 | MMAR_5155 | Activates acetate to acetyl-coenzyme A [catalytic activity: ATP + acetate + CoA = AMP + pyrophosphate + acetyl-CoA]. | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.917 |
acs_1 | citA | MMAR_3488 | MMAR_4643 | Activates acetate to acetyl-coenzyme A [catalytic activity: ATP + acetate + CoA = AMP + pyrophosphate + acetyl-CoA]. | Citrate synthase II CitA; Involved in tricarboxylic acid cycle (krebs cycle) [catalytic activity: citrate + CoA = acetyl-CoA + H2O + oxaloacetate]; Belongs to the citrate synthase family. | 0.962 |
acs_1 | glcB | MMAR_3488 | MMAR_2713 | Activates acetate to acetyl-coenzyme A [catalytic activity: ATP + acetate + CoA = AMP + pyrophosphate + acetyl-CoA]. | Malate synthase G GlcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.963 |