STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MMAR_2991Molecular chaperone (small heat shock protein); Function unknown. may be involved in a chaperoning process; Belongs to the small heat shock protein (HSP20) family. (149 aa)    
Predicted Functional Partners:
hspR_2
Involved in transcriptional regulation (repression) of heat shock proteins E.G. DnaK, GrpE, DnaJ. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock.
 
  
 0.806
hspX_1
Heat shock protein HspX_1; Thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR; Belongs to the small heat shock protein (HSP20) family.
  
     0.719
clpB
Endopeptidase ATP binding protein (chain B) ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.638
clpC2
ATP-dependent protease ATP-binding subunit ClpC2; Function unknown, possibly hydrolyzes peptides and/or proteins in presence of ATP.
  
 
 0.638
clpC1
ATP-dependent protease ATP-binding subunit ClpC1; Hydrolyses proteins in presence of ATP. may interact with a ClpP-like protease involved in degradation of denatured proteins; Belongs to the ClpA/ClpB family.
  
 
 0.638
hsp
Heat shock protein Hsp; Thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR; Belongs to the small heat shock protein (HSP20) family.
  
     0.619
MMAR_3483
Conserved hypothetical protein; Function unknown but contains N-term phosphoribosyltransferase domain and C-term eythromycin esterase.
 
  
 0.564
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
  
 
 0.561
pknK
Serine/threonine-protein kinase transcriptional regulatory protein PknK; Involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein].
  
 
 0.544
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.517
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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