STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MMAR_3812formamidopyrimidine-DNA glycosylase; Hydrolyses DNA (this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents); Belongs to the FPG family. (268 aa)    
Predicted Functional Partners:
nei
Endonuclease VIII Nei; Involved in damage reversal. DNA N-glycosylase with an ap lyase activity. required for the repair of oxidative DNA damage (oxidized pyrimidines).
  
  
 
0.927
rpiB
Ribose/galactose isomerase RpiB; Function unknown, probably involved in cellular metabolism.
 
     0.889
polA
DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.848
lhr
ATP-dependent helicase Lhr; Function unknown but has both ATPase and helicase activities.
  
  
 0.732
MMAR_3815
Conserved hypothetical protein; Function unknown but contains a DSBA-like thioredoxin domain.
 
   
 0.731
nth
Endonuclease III Nth; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
  
 0.689
MMAR_3235
Conserved hypothetical protein; Function unknown but contains domain identity with the nuclease subunit of UvrC excinucleases.
  
  
 0.662
pepN
Aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates).
       0.603
mutY
Adenine glycosylase MutY; Involved in base excision repair. removes adenine mispaired with 8-OXOG. may repair a.G and a.C mismatches by adenine excision.
  
  
 0.583
MMAR_3811
Conserved hypothetical secreted protein.
       0.562
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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