STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Coexpression
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[Homology]
Score
ECA1426Putative thiamine pyrophosphate enzyme; Similar to Bacillus subtilis acetolactate synthase large subunit IlvB SWALL:ILVB_BACSU (SWALL:P37251) (573 aa) fasta scores: E(): 5.9e-45, 32.32% id in 563 aa; Belongs to the TPP enzyme family. (598 aa)    
Predicted Functional Partners:
ECA0824
Similar to Rhodospirillum rubrum pyruvate-flavodoxin oxidoreductase NifJ SWALL:NIFJ_RHORU (SWALL:Q53046) (1191 aa) fasta scores: E(): 0, 54.73% id in 1182 aa, and to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbk or b1378 SWALL:NIFJ_ECOLI (SWALL:P52647) (1174 aa) fasta scores: E(): 0, 78.79% id in 1174 aa. Also similar to ECA2957 (47.377% id. in 1182 aa overlap).
  
 
 0.983
ilvH
Similar to Escherichia coli acetolactate synthase isozyme III small subunit IlvH or BrnP or b0078 SWALL:ILVH_ECOLI (SWALL:P00894) (163 aa) fasta scores: E(): 1.2e-48, 87.11% id in 163 aa.
 
 0.958
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
 
 0.898
ilvN
Acetolactate synthase isozyme I small subunit; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 acetolactate synthase isozyme I small subunit IlvN or b3670 or c4595 or z5164 or ecs4611 SWALL:ILVN_ECOLI (SWALL:P08143) (96 aa) fasta scores: E(): 1.9e-22, 62.5% id in 96 aa.
 
 0.879
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.878
nahM
4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 
 0.875
budB
Similar to Klebsiella pneumoniae acetolactate synthase, catabolic budb or ilvK SWALL:ILVB_KLEPN (SWALL:P27696) (559 aa) fasta scores: E(): 6.5e-143, 66% id in 556 aa, and to Klebsiella terrigena acetolactate synthase, catabolic budB SWALL:ILVB_KLETE (SWALL:Q04524) (559 aa) fasta scores: E(): 4.5e-137, 64.15% id in 558 aa; Belongs to the TPP enzyme family.
  
  
 
0.839
ilvI
Similar to Escherichia coli acetolactate synthase isozyme III large subunit IlvI or b0077 SWALL:ILVI_ECOLI (SWALL:P00893) (574 aa) fasta scores: E(): 1e-187, 83.27% id in 574 aa.
  
  
 
0.834
ilvD
Similar to Escherichia coli dihydroxy-acid dehydratase IlvD or b3771 SWALL:ILVD_ECOLI (SWALL:P05791) (616 aa) fasta scores: E(): 9.7e-207, 87.98% id in 616 aa; Belongs to the IlvD/Edd family.
 
 
 0.833
ilvG
Similar to Escherichia coli acetolactate synthase isozyme II large subunit IlvG or b3767 SWALL:ILVG_ECOLI (SWALL:P00892) (548 aa) fasta scores: E(): 9.5e-169, 80.22% id in 546 aa.
  
  
 
0.826
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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