gmk protein (Streptococcus uberis) - STRING interaction network

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gmk

Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa)

Predicted Functional Partners:

guaA

0.983

xpt

0.970

rpoZ

0.952

apt

0.944

pyk

0.937

ndk

0.933

relA

0.932

hpt

0.922

guaC

0.918

SUB1225

0.917

Your Current Organism:

Streptococcus uberis

NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SUB1225	gmk	SUB1225	SUB1391	Putative ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.917
SUB1225	guaA	SUB1225	SUB0891	Putative ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.588
SUB1225	ndk	SUB1225	SUB1084	Putative ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.921
SUB1225	pyk	SUB1225	SUB1000	Putative ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Putative pyruvate kinase; Belongs to the pyruvate kinase family.	0.910
SUB1225	relA	SUB1225	SUB0242	Putative ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.903
apt	gmk	SUB1128	SUB1391	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.944
apt	guaA	SUB1128	SUB0891	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.979
apt	guaC	SUB1128	SUB0865	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	0.930
apt	hpt	SUB1128	SUB0014	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.929
apt	xpt	SUB1128	SUB0866	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Putative xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.922
gmk	SUB1225	SUB1391	SUB1225	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Putative ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.917
gmk	apt	SUB1391	SUB1128	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.944
gmk	guaA	SUB1391	SUB0891	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.983
gmk	guaC	SUB1391	SUB0865	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	0.918
gmk	hpt	SUB1391	SUB0014	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.922
gmk	ndk	SUB1391	SUB1084	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.933
gmk	pyk	SUB1391	SUB1000	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Putative pyruvate kinase; Belongs to the pyruvate kinase family.	0.937
gmk	relA	SUB1391	SUB0242	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.932
gmk	rpoZ	SUB1391	SUB1390	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.952
gmk	xpt	SUB1391	SUB0866	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Putative xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.970