STRINGSTRING
ileS protein (Chlamydophila abortus) - STRING interaction network
"ileS" - isoleucyl-tRNA synthetase in Chlamydophila abortus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile) (1043 aa)    
Predicted Functional Partners:
pheT
phenylalanyl-tRNA synthetase subunit beta (794 aa)
   
  0.999
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction- glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (505 aa)
   
  0.974
lysS
lysyl-tRNA synthetase (526 aa)
   
  0.964
argS
arginyl-tRNA synthetase (562 aa)
   
  0.962
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (551 aa)
 
  0.960
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction- proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as ’pretransfer’ editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated ’posttransfer’ editing and involves dea [...] (577 aa)
   
  0.951
leuS
leucyl-tRNA synthetase (820 aa)
   
0.950
glyQ
glycyl-tRNA synthetase alpha chain (1005 aa)
   
   
  0.937
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (875 aa)
   
 
  0.936
cysS
cysteinyl-tRNA synthetase (476 aa)
   
   
  0.862
Your Current Organism:
Chlamydophila abortus
NCBI taxonomy Id: 218497
Other names: C. abortus, C. abortus S26/3, Chlamydia abortus, Chlamydia psittaci serotype 1, Chlamydophila abortus, Chlamydophila abortus S26/3, Chlamydophila abortus str. S26/3
Server load: low (8%) [HD]