node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEP71584.1 | hisC-2 | MCAG_01911 | MCAG_03955 | Prephenate dehydrogenase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.858 |
EEP72153.1 | hisC-2 | MCAG_02480 | MCAG_03955 | Aspartate kinase; Belongs to the aspartokinase family. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.842 |
EEP72153.1 | hisD | MCAG_02480 | MCAG_01196 | Aspartate kinase; Belongs to the aspartokinase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.456 |
EEP72153.1 | hisF | MCAG_02480 | MCAG_01186 | Aspartate kinase; Belongs to the aspartokinase family. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.683 |
EEP72153.1 | hisG | MCAG_02480 | MCAG_04910 | Aspartate kinase; Belongs to the aspartokinase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.544 |
EEP72153.1 | hisI | MCAG_02480 | MCAG_01175 | Aspartate kinase; Belongs to the aspartokinase family. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.512 |
EEP73622.1 | hisC-2 | MCAG_03949 | MCAG_03955 | P450 monooxygenase encR; Belongs to the cytochrome P450 family. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.773 |
hisA | hisB | MCAG_01190 | MCAG_01194 | Bifunctional protein hisA/trpF. | Imidazole glycerol phosphate dehydratase. | 0.998 |
hisA | hisC-2 | MCAG_01190 | MCAG_03955 | Bifunctional protein hisA/trpF. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.884 |
hisA | hisD | MCAG_01190 | MCAG_01196 | Bifunctional protein hisA/trpF. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisF | MCAG_01190 | MCAG_01186 | Bifunctional protein hisA/trpF. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | MCAG_01190 | MCAG_04910 | Bifunctional protein hisA/trpF. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.995 |
hisA | hisH | MCAG_01190 | MCAG_01192 | Bifunctional protein hisA/trpF. | Imidazole glycerol phosphate synthase hisH subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | MCAG_01190 | MCAG_01175 | Bifunctional protein hisA/trpF. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | MCAG_01194 | MCAG_01190 | Imidazole glycerol phosphate dehydratase. | Bifunctional protein hisA/trpF. | 0.998 |
hisB | hisC-2 | MCAG_01194 | MCAG_03955 | Imidazole glycerol phosphate dehydratase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.992 |
hisB | hisD | MCAG_01194 | MCAG_01196 | Imidazole glycerol phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | MCAG_01194 | MCAG_01186 | Imidazole glycerol phosphate dehydratase. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | MCAG_01194 | MCAG_04910 | Imidazole glycerol phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.991 |
hisB | hisH | MCAG_01194 | MCAG_01192 | Imidazole glycerol phosphate dehydratase. | Imidazole glycerol phosphate synthase hisH subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |