STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY0005Conserved hypothetical protein; Orthologue of E. coli yaaA (YAAA_ECOLI); Fasta hit to YAAA_ECOLI (258 aa), 86% identity in 257 aa overlap; Belongs to the UPF0246 family. (257 aa)    
Predicted Functional Partners:
STY1840
Putative membrane protein; Similar to Escherichia coli hypothetical 41.2 kDa protein in gapA-rnd intergenic region yeaN SW:YEAN_ECOLI (P76242; O07966; O07968) (393 aa) fasta scores: E(): 0, 80.9% id in 392 aa, and to Bacillus subtilis hypothetical 43.2 kDa protein in dnac-rpli intergenic region yycB SW:YYCB_BACSU (P37482) (402 aa) fasta scores: E(): 0, 43.3% id in 395 aa.
  
    0.788
STY0006
Putative amino-acid transport protein; Similar to Bacillus subtilis amino acid carrier protein alst ALST SW:ALST_BACSU (Q45068; P40743) fasta scores: E(): 0, 45.3% id in 477 aa, and to Alteromonas haloplanktis na(+)-linked D-alanine glycine permease DAGA SW:DAGA_ALTHA (P30144) fasta scores: E(): 0, 36.5% id in 315 aa; Orthologue of E. coli yaaJ (YAAJ_ECOLI); Fasta hit to YAAJ_ECOLI (476 aa), 76% identity in 476 aa overlap.
       0.648
STY3942
recF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).
      
 0.647
STY2610
Conserved hypothetical protein; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.
 
     0.481
STY0356
Conserved hypothetical protein; Orthologue of E. coli yafJ (YAFJ_ECOLI); Fasta hit to YAFJ_ECOLI (255 aa), 93% identity in 255 aa overlap.
      
 0.473
STY2724
Putative membrane protein; Orthologue of E. coli P76563; Fasta hit to P76563 (287 aa), 92% identity in 286 aa overlap. Contains hydrophobic, possible membrane-spanning region.
      
 0.468
STY3107
Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
 
     0.451
STY3943
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.418
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.