STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY0223Glutamate-1-semialdehyde 2,1-aminomutase; Fasta hit to GOAG_ECOLI (421 aa), 33% identity in 354 aa overlap; Fasta hit to GABT_ECOLI (426 aa), 32% identity in 421 aa overlap; Orthologue of E. coli hemL (GSA_ECOLI); Fasta hit to GSA_ECOLI (426 aa), 98% identity in 426 aa overlap. (426 aa)    
Predicted Functional Partners:
STY0404
Delta-aminolevulinic acid dehydratase; Orthologue of E. coli hemB (HEM2_ECOLI); Fasta hit to HEM2_ECOLI (323 aa), 94% identity in 323 aa overlap; Belongs to the ALAD family.
 
 
 0.998
STY1902
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.998
STY3621
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.978
STY0631
Enterobactin synthetase component F; Orthologue of E. coli entF (ENTF_ECOLI); Fasta hit to ENTF_ECOLI (1293 aa), 79% identity in 1294 aa overlap.
  
 
 0.915
STY0221
Ferrichrome transport protein FhuB precursor; Orthologue of E. coli fhuB (FHUB_ECOLI); Fasta hit to FHUB_ECOLI (660 aa), 90% identity in 652 aa overlap; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
      
 0.831
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
   
 0.826
STY1370
Psp operon transcriptional activator PspF; Orthologue of E. coli pspF (PSPF_ECOLI); Fasta hit to PSPF_ECOLI (325 aa), 87% identity in 326 aa overlap.
      
 0.810
STY2688
Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
     
 0.726
STY3718
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.699
menF
Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate.
  
   
 0.661
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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