STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
STY0237[protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (890 aa)    
Predicted Functional Partners:
STY2808
Nitrogen regulatory protein p-II; P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).
 
 
 0.996
STY0506
Nitrogen regulatory protein P-II; Fasta hit to GLNB_ECOLI (112 aa), 68% identity in 112 aa overlap; Orthologue of E. coli glnK (GLNK_ECOLI); Fasta hit to GLNK_ECOLI (112 aa), 97% identity in 112 aa overlap; Belongs to the P(II) protein family.
 
 
 
 0.941
STY3510
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB SW:GLTB_ECOLI (P09831) (1517 aa) fasta scores: E(): 0, 95.4% id in 1486 aa and to Pseudomonas aeruginosa glutamate synthase large subunit GltB TR:P95456 (EMBL:U81261) (1482 aa) fasta scores: E(): 0, 60.9% id in 1476 aa.
 
   
 0.925
STY3875
Two-component system sensory histidine kinase; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.
  
 
 
 0.871
amtB
Similar to Escherichia coli probable ammonium transporter AmtB SW:AMTB_ECOLI (P37905) (428 aa) fasta scores: E(): 0, 92.3% id in 428 aa, and to Xanthomonas campestris ammonium transporter AmtB TR:Q9RBJ9 (EMBL:AF182396) (491 aa) fasta scores: E(): 0, 57.9% id in 420 aa, and to Bacillus subtilis probable ammonium transporter nrgA SW:NRGA_BACSU (Q07429) (404 aa) fasta scores: E(): 0, 46.8% id in 400 aa; Orthologue of E. coli amtB (AMTB_ECOLI); Fasta hit to AMTB_ECOLI (428 aa), 92% identity in 428 aa overlap.
 
   
 0.862
STY3380
Adenyl-transferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) [...]
 
   
 0.821
STY0236
2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Orthologue of E. coli dapD (DAPD_ECOLI); Fasta hit to DAPD_ECOLI (274 aa), 96% identity in 274 aa overlap; Belongs to the transferase hexapeptide repeat family.
     
 0.758
STY3874
Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.
 
   
 0.707
STY0238
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
    0.667
STY3876
Two-component system, response regulator; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
      
 0.633
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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