STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY0985Probable transport ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (582 aa)    
Predicted Functional Partners:
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
  
 0.932
STY0984
Putative competence-related protein; Similar to Escherichia coli hypothetical protein YcaI SW:YCAI_ECOLI (P37443) (780 aa) fasta scores: E(): 0, 69.9% id in 754 aa, and to Pseudomonas stutzeri competence protein ComA TR:Q9XAU3 (EMBL:AJ243354) (741 aa) fasta scores: E(): 0, 31.1% id in 765 aa, and to Haemophilus influenzae recombination protein 2 rec2 or rec-2 or hi0061 SW:REC2_HAEIN (P44408) (788 aa) fasta scores: E(): 0, 30.6% id in 808 aa, and to Neisseria gonorrhoeae competence protein ComA comA SW:COMA_NEIGO (P51973) (691 aa) fasta scores: E(): 7.2e-24, 27.7% id in 703 aa; Ortholog [...]
     
 0.747
STY0012
DnaK protein (heat shock protein 70); Acts as a chaperone.
  
 0.639
STY4460
Putative type-1 secretion protein; Similar to Pasteurella haemolytica leukotoxin secretion ATP-binding protein LktB SW:HLYB_PASHA (P16532) (708 aa) fasta scores: E(): 0, 27.0% id in 567 aa, Salmonella typhimurium LtkB homolog SPI4_R TR:O85327 (EMBL:AF060869) (598 aa) fasta scores: E(): 0, 99.2% id in 598 aa and Escherichia coli hemolysin secretion ATP-binding protein HlyB SW:HLYB_ECOLI (P08716) (707 aa) fasta scores: E(): 3.5e-31, 24.1% id in 713 aa. Contains possible membrane spanning hydrophobic domains.
 
 
  
0.534
STY2877
Putative type I secretion protein, ATP-binding protein; Similar to many including: Actinobacillus pleuropneumoniae RTX-I toxin determinant B ApxIB SW:RT1B_ACTPL (P26760) (707 aa) fasta scores: E(): 0, 28.2% id in 698 aa, Actinobacillus actinomycetemcomitans leukotoxin secretion ATP-binding protein LktB SW:HLYB_ACTAC (P23702) (707 aa) fasta scores: E(): 0, 26.7% id in 707 aa and Escherichia coli hemolysin secretion ATP-binding protein HlyB SW:HLYB_ECOLI () (707 aa) fasta scores: E(): 0, 27.1% id in 643 aa. Contains multiple possible membrane spanning hydrophobic domains.
 
 
  
0.499
rfbP
Similar to many e.g. Salmonella typhimurium undecaprenyl-phosphate galactosephosphotransferase rfbP SW:RFBP_SALTY (P26406) (476 aa) fasta scores: E(): 0, 98.3% id in 476 aa and Salmonella typhimurium galactosyl-1-phosphate transferase RFBP4452 TR:Q54016 (EMBL:U35435) (476 aa) fasta scores: E(): 0, 98.1% id in 476 aa. Contains hydrophobic, probable membrane-spanning regions.
     
 0.470
STY0013
DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...]
  
 
 
 0.459
STY0154
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
 
   
 0.452
STY3494
Conserved hypothetical protein; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity).
 
     0.452
STY4224
Similar to Escherichia coli hypothetical ABC transporter ATP-binding protein YhiH SW:YHIH_ECOLI (P37624) (894 aa) fasta scores: E(): 0, 89.3% id in 896 aa, and to Escherichia coli hypothetical ABC transporter ATP-binding protein YbhF SW:YBHF_ECOLI (P75776) (578 aa) fasta scores: E(): 0, 35.9% id in 574 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein.
  
0.442
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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