STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1301Thymidine kinase; Orthologue of E. coli tdk (KITH_ECOLI); Fasta hit to KITH_ECOLI (205 aa), 93% identity in 204 aa overlap. (205 aa)    
Predicted Functional Partners:
STY1239
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
 
 
 0.989
STY3142
Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.969
STY4063
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.965
deoA
Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
 
  
 0.943
deoD
Similar to Escherichia coli purine nucleoside phosphorylase deod or puP SW:DEOD_ECOLI (P09743) (238 aa) fasta scores: E(): 0, 97.1% id in 238 aa.
  
 
 0.930
STY2413
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
    
 0.921
STY3765
Hypothetical protein; Similar to several 5' nucleosidase family proteins e.g. Thermotoga maritima UDP-sugar hydrolase TR:Q9X2J1 (EMBL:AE001824) (508 aa) fasta scores: E(): 1.1e-30, 32.6% id in 509 aa; Belongs to the 5'-nucleotidase family.
 
  
  0.920
STY4909
Similar to Escherichia coli hypothetical 25.3 kDa protein in rimI-prfC intergenic region YjjG SW:YJJG_ECOLI (P33999; P76818) (225 aa) fasta scores: E(): 0, 90.7% id in 225 aa, and to Bacillus subtilis YfnB TR:O06480 (EMBL:D86418) (235 aa) fasta scores: E(): 6.9e-17, 28.6% id in 227 aa.
 
  
  0.914
udp
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).
     
 0.911
STY3644
Similar to Klebsiella aerogenes uridine phosphorylase UDP SW:UDP_KLEAE (O08444) (253 aa) fasta scores: E(): 2.1e-23, 39.4% id in 218 aa, and to Escherichia coli uridine phosphorylase UDP SW:UDP_ECOLI (P12758) (252 aa) fasta scores: E(): 4.5e-23, 38.5% id in 218 aa; Fasta hit to DEOD_ECOLI (238 aa), 34% identity in 203 aa overlap; Paralogue of E. coli udp (UDP_ECOLI); Fasta hit to UDP_ECOLI (252 aa), 39% identity in 218 aa overlap.
     
 0.911
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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