STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1744Pyruvate kinase; Fasta hit to KPY2_ECOLI (479 aa), 38% identity in 480 aa overlap; Orthologue of E. coli pykF (KPY1_ECOLI); Fasta hit to KPY1_ECOLI (470 aa), 96% identity in 470 aa overlap. (470 aa)    
Predicted Functional Partners:
STY1419
Similar to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbK SW:NIFJ_ECOLI (P52647; P77238) (1174 aa) fasta scores: E(): 0, 92.9% id in 1174 aa; Orthologue of E. coli NIFJ_ECOLI; Fasta hit to NIFJ_ECOLI (1174 aa), 93% identity in 1174 aa overlap.
  
 0.989
STY3081
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
 
 0.981
maeB
NADP-dependent malate dehydrogenase (decarboxylating); Similar to Escherichia coli NADP-dependent malic enzyme maeB SW:MAO2_ECOLI (P76558) (759 aa) fasta scores: E(): 0, 94.3% id in 759 aa; Orthologue of E. coli MAO2_ECOLI; Fasta hit to MAO2_ECOLI (759 aa), 94% identity in 759 aa overlap.
  
 0.961
STY0175
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.949
STY4417
Similar to Escherichia coli glucose-6-phosphate isomerase pgi SW:G6PI_ECOLI (P11537) (549 aa) fasta scores: E(): 0, 95.3% id in 548 aa, and to Haemophilus influenzae glucose-6-phosphate isomerase pgi SW:G6PI_HAEIN (P44312) (563 aa) fasta scores: E(): 0, 75.4% id in 549 aa; Belongs to the GPI family.
  
 
 0.943
oadA
Oxaloacetate decarboxylase alpha chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
  
 
 0.935
STY1422
D-lactate dehydrogenase; Orthologue of E. coli ldhA (LDHD_ECOLI); Fasta hit to LDHD_ECOLI (329 aa), 95% identity in 328 aa overlap; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 0.931
STY1494
NAD-linked malic enzyme; Orthologue of E. coli sfcA (MAO1_ECOLI); Fasta hit to MAO1_ECOLI (574 aa), 92% identity in 572 aa overlap; Belongs to the malic enzymes family.
  
 0.929
STY4052
5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
 
 0.928
STY2096
Pyruvate kinase A; Fasta hit to KPY1_ECOLI (470 aa), 37% identity in 480 aa overlap; Orthologue of E. coli pykA (KPY2_ECOLI); Fasta hit to KPY2_ECOLI (479 aa), 98% identity in 479 aa overlap; Belongs to the pyruvate kinase family.
  
  
0.921
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.