STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
STY2126Protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)    
Predicted Functional Partners:
STY2127
Chemotaxis protein methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
  
 0.999
STY2129
Similar to many e.g. Salmonella typhimurium chemotaxis protein CheW cheW SW:CHEW_SALTY (P06110) (167 aa) fasta scores: E(): 0, 99.4% id in 167 aa; Orthologue of E. coli cheW (CHEW_ECOLI); Fasta hit to CHEW_ECOLI (167 aa), 92% identity in 167 aa overlap.
 
 
 0.999
STY2130
Chemotaxis protein CheA; Similar to many e.g. Salmonella typhimurium chemotaxis protein CheA cheA SW:CHEA_SALTY (P09384) (671 aa) fasta scores: E(): 0, 99.4% id in 671 aa; Orthologue of E. coli cheA (CHEA_ECOLI); Fasta hit to CHEA_ECOLI (654 aa), 85% identity in 672 aa overlap.
 
 0.999
STY2125
Chemotaxis protein CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity).
 
 
 0.997
STY2124
Chemotaxis protein CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).
 
  
 0.994
STY2128
Similar to Salmonella typhimurium methyl-accepting chemotaxis protein II tar SW:MCP2_SALTY (P02941) (553 aa) fasta scores: E(): 0, 98.7% id in 553 aa. Contains a possible N-terminal signal sequence and hydrophobic, probable membrane-spanning region; Fasta hit to MCP3_ECOLI (546 aa), 47% identity in 523 aa overlap; Fasta hit to MCP4_ECOLI (533 aa), 48% identity in 523 aa overlap; Fasta hit to MCP1_ECOLI (551 aa), 59% identity in 557 aa overlap; Orthologue of E. coli tar (MCP2_ECOLI); Fasta hit to MCP2_ECOLI (553 aa), 79% identity in 554 aa overlap.
 
 0.993
STY3395
Aerotaxis receptor protein; Orthologue of E. coli air (AER_ECOLI); Fasta hit to AER_ECOLI (506 aa), 84% identity in 506 aa overlap.
 
 0.991
cheM
Similar to many including: Escherichia coli methyl-accepting chemotaxis protein II Tar or CheM SW:MCP2_ECOLI (P07017; P76301) (553 aa) fasta scores: E(): 0, 34.7% id in 519 aa; Fasta hit to MCP3_ECOLI (546 aa), 35% identity in 524 aa overlap; Fasta hit to MCP4_ECOLI (533 aa), 33% identity in 525 aa overlap; Fasta hit to MCP1_ECOLI (551 aa), 37% identity in 531 aa overlap; Paralogue of E. coli tar (MCP2_ECOLI); Fasta hit to MCP2_ECOLI (553 aa), 35% identity in 519 aa overlap.
 
 0.986
STY4234
Similar to Salmonella typhimurium methyl-accepting chemotaxis citrate transducer tcp SW:MCPC_SALTY (Q02755) (547 aa) fasta scores: E(): 0, 99.8% id in 547 aa, and to Escherichia coli methyl-accepting chemotaxis protein I CheD SW:MCP1_ECOLI (P02942) (551 aa) fasta scores: E(): 0, 53.4% id in 554 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein.
 
 0.984
STY2545
Putative receptor/regulator protein; Shows weak similarity to Bacillus subtilis chemotaxis CheV protein cheV SW:CHEV_BACSU (P37599) (303 aa) fasta scores: E(): 2.7e-17, 31.4% id in 299 aa and e.g. Vibrio parahaemolyticus chemotaxis CheV homolog cheV TR:Q9X9K3 (EMBL:U12817) (308 aa) fasta scores: E(): 5.7e-26, 32.6% id in 322 aa.
 
 
 0.975
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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