STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY2171Similar to Salmonella typhimurium cytoplasmic alpha-amylase amyA SW:AMY2_SALTY (P26613) (494 aa) fasta scores: E(): 0, 98.4% id in 494 aa; Orthologue of E. coli amyA (AMY2_ECOLI); Fasta hit to AMY2_ECOLI (495 aa), 89% identity in 494 aa overlap. (494 aa)    
Predicted Functional Partners:
STY4282
Maltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
 0.976
glgX
Glycogen operon protein; Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.
  
 
 0.961
glgP
Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
 0.960
STY4134
Alpha-amylase; Orthologue of E. coli malS (AMY1_ECOLI); Fasta hit to AMY1_ECOLI (676 aa), 82% identity in 676 aa overlap. Contains a probable N-terminal signal sequence.
 
   
 0.957
glgB
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
  
 
 0.931
malQ
4-alpha-glucanotransferase; Similar to Escherichia coli 4-alpha-glucanotransferase MalQ SW:MALQ_ECOLI (P15977) (694 aa) fasta scores: E(): 0, 84.9% id in 694 aa, and to Haemophilus influenzae 4-alpha-glucanotransferase MalQ SW:MALQ_HAEIN (P45176) (699 aa) fasta scores: E(): 0, 41.1% id in 635 aa.
  
 
 0.920
STY1504
Putative hydrolase; Similar to Rhizobium sp maltooligosyl trehalose synthase treY TR:Q53237 (EMBL:D78001) (772 aa) fasta scores: E(): 4.7e-26, 37.0% id in 832 aa.
  
 
 0.917
STY0439
Maltodextrin glucosidase; Orthologue of E. coli malZ (MALZ_ECOLI); Fasta hit to MALZ_ECOLI (605 aa), 83% identity in 604 aa overlap; Belongs to the glycosyl hydrolase 13 family.
     
 0.902
STY0723
Pts system, N-acetylglucosamine-specific IIABC component; Orthologue of E. coli nagE (PTAA_ECOLI); Fasta hit to PTAA_ECOLI (648 aa), 93% identity in 648 aa overlap.
  
  
 0.718
fliT
Flagellar protein FliT; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
       0.715
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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