STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pduASimilar to Salmonella typhimurium propanediol utilization protein PduA pduA SW:PDUA_SALTY (P37448) (97 aa) fasta scores: E(): 5.7e-31, 100.0% id in 90 aa and identical to Salmonella enterica serovar Typhimurium PduA pduA TR:AAB84107 (EMBL:AF026270) (94 aa) fasta scores: E(): 1.1e-32, 100.0% id in 94 aa. S. typhi pduA is probably not essential for propanediol catabolism (by similarity), but may be involved (cf. homologue in the eut operon). The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the [...] (94 aa)    
Predicted Functional Partners:
pduT
Putative propanediol utilization protein PduT; Similar to Salmonella enterica serovar Typhimurium protein PduT pduT TR:Q9XDM8 (EMBL:AF026270) (184 aa) fasta scores: E(): 0, 98.9% id in 184 aa and to part of Salmonella typhimurium ethanolamine utilization protein EutM precursor eutM or cchA SW:EUTM_SALTY (P41791) (96 aa) fasta scores: E(): 0.00067, 40.0% id in 80 aa. The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the dehydratase from oxygen.
 
 
 
 0.988
pduB
Similar to Salmonella typhimurium propanediol utilization protein PduB pduB SW:PDUB_SALTY (P37449) (233 aa) fasta scores: E(): 0, 99.1% id in 233 aa. S. typhi pduB is probably not essential for propanediol catabolism (by similarity), but may be involved (cf. homologue in the eut operon). The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the dehydratase from oxygen.
 
  
 0.985
pduP
Putative CoA-dependent proprionaldehyde dehydrogenase; Similar to Salmonella enterica serovar Typhimurium protein PduP pduP TR:Q9XDN1 (EMBL:AF026270) (464 aa) fasta scores: E(): 0, 99.1% id in 464 aa and Salmonella typhimurium ethanolamine utilization protein EutE eutE SW:EUTE_SALTY (P41793) (467 aa) fasta scores: E(): 0, 45.7% id in 473 aa; Paralogue of E. coli eutE (EUTE_ECOLI); Fasta hit to EUTE_ECOLI (467 aa), 45% identity in 470 aa overlap.
 
  
 0.985
STY2260
Identical to Salmonella typhimurium propanediol utilization protein pduU SW:PDUU_SALTY (Q9XDM7) (116 aa) fasta scores: E(): 0, 100.0% id in 116 aa and Salmonella typhimurium ethanolamine utilization protein eutS SW:EUTS_SALTY (P76557) (111 aa) fasta scores: E(): 3.4e-22, 57.8% id in 109 aa. The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the dehydratase from oxygen.
 
  
 0.976
pduD
Similar to Salmonella typhimurium diol dehydratase medium subunit pduD TR:O31041 (EMBL:AF026270) (224 aa) fasta scores: E(): 0, 98.2% id in 224 aa and Klebsiella oxytoca diol dehydratase beta subunit pddB TR:Q59471 (EMBL:D45071) (224 aa) fasta scores: E(): 0, 95.1% id in 224 aa.
 
  
 0.960
pduC
Similar to Salmonella typhimurium glycerol dehydratase large subunit pduC SW:DHAB_SALTY (P37450) (554 aa) fasta scores: E(): 0, 99.6% id in 554 aa and Klebsiella oxytoca diol dehydratase alpha subunit pddA TR:Q59470 (EMBL:D45071) (554 aa) fasta scores: E(): 0, 99.6% id in 554 aa.
 
  
 0.949
pduE
Similar to Salmonella typhimurium diol dehydratase small subunit pduE TR:O31042 (EMBL:AF026270) (173 aa) fasta scores: E(): 0, 99.4% id in 173 aa, and to Klebsiella oxytoca diol dehydratase gamma pddC TR:Q59472 (EMBL:D45071) (173 aa) fasta scores: E(): 0, 96.5% id in 173 aa.
 
  
 0.932
pduL
Conserved hypothetical protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.
 
  
 0.926
eutS
Putative ethanolamine utilization protein EutS; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the EutS/PduU family.
 
  
 0.920
pduG
PduG protein; Similar to Salmonella enterica serovar Typhimurium protein PduG pduG TR:O31043 (EMBL:AF026270) (610 aa) fasta scores: E(): 0, 99.0% id in 610 aa and Klebsiella oxytoca diol dehydratase-reactivating factor large subunit ddrA TR:O68195 (EMBL:AF017781) (610 aa) fasta scores: E(): 0, 95.4% id in 608 aa. May be involved in removing inactive cofactor from the PduCDE dehydratase. Possibly also an adenosyltransferase (experimental).
 
  
 0.866
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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