node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STY0002 | STY2280 | gene:17584057 | gene:17586188 | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.824 |
STY0002 | STY2281 | gene:17584057 | gene:17586189 | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.952 |
STY0002 | STY2282 | gene:17584057 | gene:17586190 | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Similar to Salmonella typhimurium histidinol-phosphate aminotransferase hisC SW:HIS8_SALTY (P10369) (359 aa) fasta scores: E(): 0, 98.6% id in 359 aa; Orthologue of E. coli hisC (HIS8_ECOLI); Fasta hit to HIS8_ECOLI (356 aa), 89% identity in 355 aa overlap; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.864 |
STY0002 | STY2283 | gene:17584057 | gene:17586191 | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Imidazoleglycerol-phosphate dehydratase; Similar to Salmonella typhimurium histidine biosynthesis bifunctional protein HisB [includes: histidinol-phosphatase hisB SW:HIS7_SALTY (P10368) (354 aa) fasta scores: E(): 0, 97.5% id in 355 aa; Orthologue of E. coli hisB (HIS7_ECOLI); Fasta hit to HIS7_ECOLI (355 aa), 96% identity in 355 aa overlap; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.861 |
STY0002 | STY2285 | gene:17584057 | gene:17586193 | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Similar to Salmonella typhimurium phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA SW:HIS4_SALTY (P10372) (246 aa) fasta scores: E(): 0, 96.3% id in 246 aa; Orthologue of E. coli hisA (HIS4_ECOLI); Fasta hit to HIS4_ECOLI (245 aa), 94% identity in 244 aa overlap. | 0.590 |
STY0002 | STY2286 | gene:17584057 | gene:17586194 | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cyclase HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.653 |
STY0002 | STY2287 | gene:17584057 | gene:17586195 | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; Similar to Salmonella typhimurium histidine biosynthesis bifunctional protein HisI [includes: phosphoribosyl-AMP cyclohydrolase hisI SW:HIS2_SALTY (P10367) (203 aa) fasta scores: E(): 0, 97.5% id in 203 aa; Orthologue of E. coli hisI (HIS2_ECOLI); Fasta hit to HIS2_ECOLI (203 aa), 91% identity in 203 aa overlap; In the C-terminal section; belongs to the PRA-PH family. | 0.875 |
STY0002 | STY2616 | gene:17584057 | gene:17586513 | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.944 |
STY2280 | STY0002 | gene:17586188 | gene:17584057 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.824 |
STY2280 | STY2281 | gene:17586188 | gene:17586189 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
STY2280 | STY2282 | gene:17586188 | gene:17586190 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Similar to Salmonella typhimurium histidinol-phosphate aminotransferase hisC SW:HIS8_SALTY (P10369) (359 aa) fasta scores: E(): 0, 98.6% id in 359 aa; Orthologue of E. coli hisC (HIS8_ECOLI); Fasta hit to HIS8_ECOLI (356 aa), 89% identity in 355 aa overlap; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.996 |
STY2280 | STY2283 | gene:17586188 | gene:17586191 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazoleglycerol-phosphate dehydratase; Similar to Salmonella typhimurium histidine biosynthesis bifunctional protein HisB [includes: histidinol-phosphatase hisB SW:HIS7_SALTY (P10368) (354 aa) fasta scores: E(): 0, 97.5% id in 355 aa; Orthologue of E. coli hisB (HIS7_ECOLI); Fasta hit to HIS7_ECOLI (355 aa), 96% identity in 355 aa overlap; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
STY2280 | STY2284 | gene:17586188 | gene:17586192 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.993 |
STY2280 | STY2285 | gene:17586188 | gene:17586193 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Similar to Salmonella typhimurium phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA SW:HIS4_SALTY (P10372) (246 aa) fasta scores: E(): 0, 96.3% id in 246 aa; Orthologue of E. coli hisA (HIS4_ECOLI); Fasta hit to HIS4_ECOLI (245 aa), 94% identity in 244 aa overlap. | 0.995 |
STY2280 | STY2286 | gene:17586188 | gene:17586194 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Cyclase HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.995 |
STY2280 | STY2287 | gene:17586188 | gene:17586195 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; Similar to Salmonella typhimurium histidine biosynthesis bifunctional protein HisI [includes: phosphoribosyl-AMP cyclohydrolase hisI SW:HIS2_SALTY (P10367) (203 aa) fasta scores: E(): 0, 97.5% id in 203 aa; Orthologue of E. coli hisI (HIS2_ECOLI); Fasta hit to HIS2_ECOLI (203 aa), 91% identity in 203 aa overlap; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
STY2281 | STY0002 | gene:17586189 | gene:17584057 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.952 |
STY2281 | STY2280 | gene:17586189 | gene:17586188 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.997 |
STY2281 | STY2282 | gene:17586189 | gene:17586190 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Similar to Salmonella typhimurium histidinol-phosphate aminotransferase hisC SW:HIS8_SALTY (P10369) (359 aa) fasta scores: E(): 0, 98.6% id in 359 aa; Orthologue of E. coli hisC (HIS8_ECOLI); Fasta hit to HIS8_ECOLI (356 aa), 89% identity in 355 aa overlap; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
STY2281 | STY2283 | gene:17586189 | gene:17586191 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Imidazoleglycerol-phosphate dehydratase; Similar to Salmonella typhimurium histidine biosynthesis bifunctional protein HisB [includes: histidinol-phosphatase hisB SW:HIS7_SALTY (P10368) (354 aa) fasta scores: E(): 0, 97.5% id in 355 aa; Orthologue of E. coli hisB (HIS7_ECOLI); Fasta hit to HIS7_ECOLI (355 aa), 96% identity in 355 aa overlap; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |