STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
rfbFGlucose-1-phosphate cytidylyltransferase; Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate. This enzyme can utilize either CTP or UTP as the nucleotide donor; Belongs to the glucose-1-phosphate cytidylyltransferase family. (257 aa)    
Predicted Functional Partners:
rfbG
CDP-glucose 4,6-dehydratase; Similar to Salmonella typhimurium LT2, group B, CDP-glucose 4,6-dehydratase rfbG SW:RFBG_SALTY (P26397) (359 aa) fasta scores: E(): 0, 99.2% id in 359 aa.
 
 0.999
rfbH
Putative dehydratase RfbH; Similar to many e.g. Salmonella typhimurium strain LT2, group B, lipopolysaccharide biosynthesis protein RfbH rfbH SW:RFBH_SALTY (P26398) (437 aa) fasta scores: E(): 0, 99.5% id in 437 aa and Yersinia pseudotuberculosis CDP-4-keto-6-deoxy-D-glucose-3-dehydrase ddhC TR:Q05341 (EMBL:L01777) (437 aa) fasta scores: E(): 0, 87.4% id in 437 aa; Belongs to the DegT/DnrJ/EryC1 family.
 
  
 0.981
STY2304
dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
  
  
 0.974
STY2308
UTP-glucose-1-phosphate uridylyltransferase; May play a role in stationary phase survival; Belongs to the UDPGP type 2 family.
    
 0.948
rfbI
Putative reductase RfbI; Similar to Salmonella typhimurium LT2, group B, RfbI protein rfbI SW:RFBI_SALTY (P26395) (330 aa) fasta scores: E(): 0, 99.1% id in 323 aa and Yersinia pseudotuberculosis CDP-6-deoxy-delta-3,4-glucoseen reductase ascD or rfbI SW:ASCD_YERPS (P37911) (328 aa) fasta scores: E(): 0, 51.7% id in 327 aa.
  
 
 0.946
STY4114
Selenocysteine-specific elongation factor; Orthologue of E. coli selB (SELB_ECOLI); Fasta hit to SELB_ECOLI (614 aa), 85% identity in 615 aa overlap.
    
 0.942
glgC
Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
    
 0.939
rfbS
Paratose synthase; Catalyzes synthesis of paratose and tyvelose, unusual 3,6- dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
 
 
 0.938
glgP
Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
 0.933
STY0736
Phosphoglucomutase; Orthologue of E. coli pgm (PGMU_ECOLI); Fasta hit to PGMU_ECOLI (546 aa), 98% identity in 546 aa overlap.
   
 0.928
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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