STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
STY2869Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa)    
Predicted Functional Partners:
STY1803
NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.949
nadR
Conserved hypothetical transcriptional regulator; Bifunctional protein. DNA binding, contains helix-turn-helix. Transporter, interacts with NcuC transporting NMN into the cell. Similar to Salmonella typhimurium transcriptional regulator NadR SW:NADR_SALTY (P24518) (409 aa) fasta scores: E(): 0, 98.8% id in 410 aa, and to Escherichia coli transcriptional regulator NadR SW:NADR_ECOLI (P27278; P76819) (410 aa) fasta scores: E(): 0, 94.6% id in 409 aa.
  
 
 0.948
STY0696
Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.947
STY1589
Pyridine nucleotide transhydrogenase subunit-alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family.
     
 0.928
cobB
Putative regulatory protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.
  
 
 0.925
STY3748
Possible pyridine nucleotide-disulphide oxidoreductase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
     
 0.909
STY1588
Pyridine nucleotide transhydrogenase subunit-beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.906
STY3083
Conserved hypothetical protein; Orthologue of E. coli mazG (MAZG_ECOLI); Fasta hit to MAZG_ECOLI (263 aa), 94% identity in 262 aa overlap.
     
 0.901
STY3719
Conserved hypothetical protein; Orthologue of E. coli yjaD (YJAD_ECOLI); Fasta hit to YJAD_ECOLI (257 aa), 92% identity in 257 aa overlap.
     
 0.901
STY2868
Heat shock protein GrpE (heat shock protein b25.3) (hsp24); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the rea [...]
 
     0.646
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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