STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
stpATyrosine phosphatase (associated with virulence); Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear (By similarity). (543 aa)    
Predicted Functional Partners:
sicP
Chaperone (associated with virulence); Molecular chaperone required for SptP stabilization and secretion; Belongs to the SicP family.
  
 
 0.999
sipC
Pathogenicity island 1 effector protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell (By similarity).
  
  
 0.987
sipA
Pathogenicity island 1 effector protein (function unknown); Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization (By similarity). Belongs to the SipA/IpaA family.
  
  
 0.978
sspH2
Similar to Salmonella typhimurium secreted protein SspH2 TR:Q9RPH0 (EMBL:AF160727) (788 aa) fasta scores: E(): 0, 99.6% id in 788 aa and to many secreted, leucine-rich-repeat proteins e.g. Shigella flexneri 65.4 kDa antigen IpaH 4.5 SW:IPA4_SHIFL (P18009) (574 aa) fasta scores: E(): 0, 44.9% id in 515 aa.
  
   
 0.970
sipB
Pathogenicity island 1 effector protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in associat [...]
  
  
 0.939
sigD
Cell invasion protein; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicl [...]
   
  
 0.927
invG
Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence.
 
  
 0.909
spaT
Unknown function; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE (By similarity).
 
 
 0.906
sipD
Pathogenicity island 1 effector protein; Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC (By similarity).
  
  
 0.891
STY3504
Conserved hypothetical protein; Orthologue of E. coli YRBL_ECOLI; Fasta hit to YRBL_ECOLI (210 aa), 77% identity in 210 aa overlap.
  
 
 0.873
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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