STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
invFPossible AraC-family regulatory protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE (By similarity). (216 aa)    
Predicted Functional Partners:
spaT
Unknown function; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE (By similarity).
  
  
 0.961
invE
Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity).
  
  
 0.947
invG
Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence.
  
  
 0.924
sprA
Possible AraC-family transcriptional regulator; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1).
   
  
 0.896
invA
Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
     
 0.890
STY2996
AraC-family transcriptional regulator; Similar to several from Salmonella typhimurium including: TR:Q9X5C3 (EMBL:AF124398) HilD transcriptional regulator (309 aa) fasta scores: E(): 0, 99.4% id in 309 aa and SW:YGBG_SALTY (P41782) hypothetical 17.2 kDa protein found upstream of prgH fasta scores: E(): 0, 87.9% id in 132 aa.
   
  
 0.889
sipB
Pathogenicity island 1 effector protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in associat [...]
  
  
 0.848
sipC
Pathogenicity island 1 effector protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell (By similarity).
  
  
 0.842
sipA
Pathogenicity island 1 effector protein (function unknown); Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization (By similarity). Belongs to the SipA/IpaA family.
     
 0.823
spak
Secretory protein (associated with virulence); Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
  
  
 0.820
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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