STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY3218D-3-phosphoglycerate dehydrogenase; Orthologue of E. coli serA (SERA_ECOLI); Fasta hit to SERA_ECOLI (409 aa), 96% identity in 409 aa overlap; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)    
Predicted Functional Partners:
STY0977
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 0.973
STY0804
Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
  
 0.908
gpmB
Similar to Escherichia coli probable phosphoglycerate mutase 2 gpmB SW:PMG2_ECOLI (P36942) (215 aa) fasta scores: E(): 0, 90.2% id in 215 aa.
  
 
 0.904
STY4091
2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
     
 0.902
STY1467
Putative aldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
   
 
 0.759
STY1536
Similar to Escherichia coli aldehyde-dehydrogenase like protein YneI yneI SW:YNEI_ECOLI (P76149; P78220) (462 aa) fasta scores: E(): 0, 79.6% id in 353 aa, and to Escherichia coli aldehyde dehydrogenase A aldA SW:ALDA_ECOLI (P25553) (478 aa) fasta scores: E(): 0, 36.8% id in 348 aa. Contains C-terminal truncation.
   
 
 0.759
STY3298
Similar to Escherichia coli phenylacetaldehyde dehydrogenase feaB SW:FEAB_ECOLI (P80668; P46884; P77637; O32557) (499 aa) fasta scores: E(): 0, 43.8% id in 495 aa.
   
 
 0.759
STY0002
Aspartokinase I/homoserine dehydrogenase I; Orthologue of E. coli thrA (AK1H_ECOLI); Fasta hit to AK1H_ECOLI (820 aa), 94% identity in 820 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.636
STY3768
Bifunctional aspartokinase II/homoserine dehydrogenase IIcan I write; Fasta hit to AK1H_ECOLI (820 aa), 30% identity in 823 aa overlap; Orthologue of E. coli metL (AK2H_ECOLI); Fasta hit to AK2H_ECOLI (809 aa), 94% identity in 809 aa overlap; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.636
STY2779
Putative thiosulfate sulfurtransferase; Similar to many eukaryotic proteins e.g. Homo sapiens 3-mercaptopyruvate sulfurtransferase mpsT or tst2 SW:THTM_HUMAN (P25325) (296 aa) fasta scores: E(): 0, 41.1% id in 280 aa; Orthologue of E. coli sseA (THTR_ECOLI); Fasta hit to THTR_ECOLI (280 aa), 81% identity in 278 aa overlap.
      
 0.628
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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