STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY3355Probable two-component system sensor histidine kinase; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation (By similarity). (449 aa)    
Predicted Functional Partners:
STY3354
Probable two-component system response regulator; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of flhDC (By similarity).
 
 0.999
STY0743
KDP operon transcriptional regulatory protein; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 218 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 34% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 36% identity in 219 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 33% identity in 221 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 34% identity in 231 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 34% identity in 220 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 31% identity in 228 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 30% identity in 227 aa overlap; Fasta hit to PHOB [...]
 
 0.994
STY2809
Similar to many e.g. Escherichia coli transcriptional regulatory protein HydG hydG SW:HYDG_ECOLI (P14375) (441 aa) fasta scores: E(): 0, 44.6% id in 439 aa and Pseudomonas aeruginosa type 4 fimbriae expression regulatory protein PilR pilR SW:PILR_PSEAE (Q00934) (446 aa) fasta scores: E(): 0, 40.2% id in 443 aa; Fasta hit to HYDG_ECOLI (441 aa), 45% identity in 439 aa overlap; Fasta hit to NTRC_ECOLI (469 aa), 42% identity in 404 aa overlap; Fasta hit to YGAA_ECOLI (529 aa), 37% identity in 449 aa overlap; Fasta hit to ATOC_ECOLI (461 aa), 41% identity in 454 aa overlap; Orthologue of E [...]
   
 0.926
STY3507
Aerobic respiration control sensor protein; Orthologue of E. coli arcB (ARCB_ECOLI); Fasta hit to ARCB_ECOLI (776 aa), 94% identity in 778 aa overlap.
 
 
 0.859
pmrA
Two-component response regulator; Similar to Salmonella typhimurium transcriptional regulatory protein PmrA or BasR SW:BASR_SALTY (P36556) (222 aa) fasta scores: E(): 0, 98.6% id in 222 aa, and to Escherichia coli transcriptional regulatory protein BasR SW:BASR_ECOLI (P30843) (222 aa) fasta scores: E(): 0, 90.1% id in 222 aa.
 
 
 0.831
STY3353
Possible exported protein; Fasta hit to YDEI_ECOLI (130 aa), 33% identity in 129 aa overlap; Orthologue of E. coli YGIW_ECOLI; Fasta hit to YGIW_ECOLI (130 aa), 89% identity in 130 aa overlap. Contains a possible N-terminal signal sequence.
 
   
 0.820
STY3951
Two-component sensor protein histidine protein kinase; Orthologue of E. coli torS (TORS_ECOLI); Fasta hit to TORS_ECOLI (904 aa), 63% identity in 898 aa overlap.
 
 
 0.807
tctD
Similar to Salmonella typhimurium transcriptional regulatory protein TctD SW:TCTD_SALTY (P22104) (224 aa) fasta scores: E(): 0, 99.1% id in 224 aa and Salmonella typhi AJB70 TctD protein TR:O68288 (EMBL:AF029846) (223 aa) fasta scores: E(): 0, 97.3% id in 224 aa; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 226 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 33% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 38% identity in 226 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 37% identity in 220 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 36% identity in 228 aa overlap [...]
 
 
 0.734
STY1271
Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells.
 
 
 0.727
STY3812
Two-component response regulatory protein; Fasta hit to TORR_ECOLI (230 aa), 32% identity in 233 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 39% identity in 226 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 36% identity in 232 aa overlap; Fasta hit to RSTA_ECOLI (242 aa), 34% identity in 233 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 37% identity in 231 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 40% identity in 230 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 36% identity in 228 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 34% identity in 228 aa overlap; Fasta hit to PHOB_ECO [...]
 
 
 0.706
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.