STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
STY3521Putative GntR-family transcriptional regulator; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. (263 aa)    
Predicted Functional Partners:
STY3519
Putative sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
 
   
 0.939
STY3520
N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
 
   
 0.907
STY3515
Conserved hypothetical protein; Fasta hit to YJGK_ECOLI (150 aa), 32% identity in 148 aa overlap; Orthologue of E. coli YHCH_ECOLI; Fasta hit to YHCH_ECOLI (154 aa), 81% identity in 154 aa overlap.
      
 0.801
STY4103
Putative L-lactate dehydrogenase operon regulator; Fasta hit to PDHR_ECOLI (254 aa), 39% identity in 254 aa overlap; Fasta hit to UXUR_ECOLI (257 aa), 32% identity in 235 aa overlap; Orthologue of E. coli lctR (LLDR_ECOLI); Fasta hit to LLDR_ECOLI (258 aa), 86% identity in 258 aa overlap.
  
     0.760
STY3516
Possible kinase; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily.
 
   
 0.711
STY0722
Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
     
 0.580
STY3522
Stringent starvation protein B; Orthologue of E. coli sspB (SSPB_ECOLI); Fasta hit to SSPB_ECOLI (165 aa), 89% identity in 167 aa overlap.
  
    0.551
STY3523
Stringent starvation protein A; Orthologue of E. coli sspA (SSPA_ECOLI); Fasta hit to SSPA_ECOLI (211 aa), 98% identity in 210 aa overlap; Belongs to the GST superfamily.
       0.517
nadR
Conserved hypothetical transcriptional regulator; Bifunctional protein. DNA binding, contains helix-turn-helix. Transporter, interacts with NcuC transporting NMN into the cell. Similar to Salmonella typhimurium transcriptional regulator NadR SW:NADR_SALTY (P24518) (409 aa) fasta scores: E(): 0, 98.8% id in 410 aa, and to Escherichia coli transcriptional regulator NadR SW:NADR_ECOLI (P27278; P76819) (410 aa) fasta scores: E(): 0, 94.6% id in 409 aa.
   
  
 0.490
wecB
UDP-N-acetyl-D-glucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
      
 0.468
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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