STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY3546Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (310 aa)    
Predicted Functional Partners:
STY3545
Putative membrane protein; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell; Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
 
  
 0.983
STY3546a
Similar to Escherichia coli hypothetical protein YhcR SW:YHCR_ECOLI (P46478) (90 aa) fasta scores: E(): 5.6e-29, 98.5% id in 67 aa.
 
    0.941
ybjZ
Conserved hypothetical ABC transporter; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.780
STY3547
Probable LysR-family transcriptional regulator; Fasta hit to YHJC_ECOLI (299 aa), 31% identity in 293 aa overlap; Fasta hit to YAFC_ECOLI (304 aa), 31% identity in 290 aa overlap; Fasta hit to YEAT_ECOLI (307 aa), 30% identity in 293 aa overlap; Orthologue of E. coli YHCS_ECOLI; Fasta hit to YHCS_ECOLI (309 aa), 95% identity in 309 aa overlap; Belongs to the LysR transcriptional regulatory family.
 
   
 0.690
STY0381
Possible transcriptionl regulator; Similar to Salmonella typhimurium hypothetical 24.8 kDa protein TR:Q9RFV5 (EMBL:AF166275) (213 aa) fasta scores: E(): 0, 99.4% id in 175 aa, and to Klebsiella pneumoniae Rmpa2 rmpa2 TR:Q53343 (EMBL:S64176) (212 aa) fasta scores: E(): 1.7e-12, 31.9% id in 160 aa, and weakly to the C-terminus of Corynebacterium diphtheriae response regulator CstA cstA TR:Q9RPE7 (EMBL:AF161328) (233 aa) fasta scores: E(): 0.33, 34.3% id in 67 aa, and Salmonella typhimurium transcriptional regulatory protein UhpA uhpA SW:UHPA_SALTY (P27667) (196 aa) fasta scores: E(): 0.7 [...]
   
  
 0.656
STY2279
Conserved hypothetical protein; Similar to e.g Deinococcus radiodurans conserved hypothetical protein DR0832 TR:Q9RW37 (EMBL:AE001937) (290 aa) fasta scores: E(): 3.1e-32, 40.8% id in 272 aa, Neisseria meningitidis hypothetical protein NMA1019 TR:Q9JV30 (EMBL:AL162754) (258 aa) fasta scores: E(): 3.6e-16, 31.0% id in 261 aa and to Neisseria meningitidis hypothetical protein NMB0809 TR:Q9K018 (EMBL:AE002434) (265 aa) fasta scores: E(): 4e-15, 31.2% id in 263 aa; Orthologue of E. coli YEEZ_ECOLI; Fasta hit to YEEZ_ECOLI (274 aa), 89% identity in 274 aa overlap.
      
 0.647
STY2402
Putative lipoprotein; Shows weak similarity to e.g. Pseudomonas aeruginosa outer membrane protein OprM precursor oprM or oprK SW:OPRM_PSEAE (Q51487; Q51444) (477 aa) fasta scores: E(): 7.1e-20, 25.5% id in 491 aa. Contains probable N-terminal signal sequence; Fasta hit to YJCP_ECOLI (488 aa), 37% identity in 488 aa overlap; Orthologue of E. coli yohG (YOHG_ECOLI); Fasta hit to YOHG_ECOLI (398 aa), 85% identity in 396 aa overlap.
 
 
 0.644
STY2941
Multidrug resistance protein B; Fasta hit to YIEO_ECOLI (475 aa), 33% identity in 424 aa overlap; Fasta hit to EMRY_ECOLI (512 aa), 63% identity in 506 aa overlap; Orthologue of E. coli emrB (EMRB_ECOLI); Fasta hit to EMRB_ECOLI (512 aa), 96% identity in 512 aa overlap; Belongs to the major facilitator superfamily.
  
 
 0.640
tolC
Similar to Salmonella enteritidis outer membrane protein TolC precursor tolC SW:TOLC_SALEN (Q54001) (491 aa) fasta scores: E(): 0, 99.0% id in 491 aa, and to Escherichia coli outer membrane protein tolc precursor tolc or mtcb or muka or refI SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 89.7% id in 495 aa; Orthologue of E. coli tolC (TOLC_ECOLI); Fasta hit to TOLC_ECOLI (495 aa), 90% identity in 495 aa overlap.
 
 
 0.585
STY0520
Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
  
 0.572
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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