node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STY0381 | STY3546 | gene:17584410 | gene:17587393 | Possible transcriptionl regulator; Similar to Salmonella typhimurium hypothetical 24.8 kDa protein TR:Q9RFV5 (EMBL:AF166275) (213 aa) fasta scores: E(): 0, 99.4% id in 175 aa, and to Klebsiella pneumoniae Rmpa2 rmpa2 TR:Q53343 (EMBL:S64176) (212 aa) fasta scores: E(): 1.7e-12, 31.9% id in 160 aa, and weakly to the C-terminus of Corynebacterium diphtheriae response regulator CstA cstA TR:Q9RPE7 (EMBL:AF161328) (233 aa) fasta scores: E(): 0.33, 34.3% id in 67 aa, and Salmonella typhimurium transcriptional regulatory protein UhpA uhpA SW:UHPA_SALTY (P27667) (196 aa) fasta scores: E(): 0.7 [...] | Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.656 |
STY0520 | STY2402 | gene:17584541 | gene:17586307 | Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Putative lipoprotein; Shows weak similarity to e.g. Pseudomonas aeruginosa outer membrane protein OprM precursor oprM or oprK SW:OPRM_PSEAE (Q51487; Q51444) (477 aa) fasta scores: E(): 7.1e-20, 25.5% id in 491 aa. Contains probable N-terminal signal sequence; Fasta hit to YJCP_ECOLI (488 aa), 37% identity in 488 aa overlap; Orthologue of E. coli yohG (YOHG_ECOLI); Fasta hit to YOHG_ECOLI (398 aa), 85% identity in 396 aa overlap. | 0.802 |
STY0520 | STY2941 | gene:17584541 | gene:17586831 | Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Multidrug resistance protein B; Fasta hit to YIEO_ECOLI (475 aa), 33% identity in 424 aa overlap; Fasta hit to EMRY_ECOLI (512 aa), 63% identity in 506 aa overlap; Orthologue of E. coli emrB (EMRB_ECOLI); Fasta hit to EMRB_ECOLI (512 aa), 96% identity in 512 aa overlap; Belongs to the major facilitator superfamily. | 0.781 |
STY0520 | STY3546 | gene:17584541 | gene:17587393 | Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.572 |
STY0520 | tolC | gene:17584541 | gene:17587221 | Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Similar to Salmonella enteritidis outer membrane protein TolC precursor tolC SW:TOLC_SALEN (Q54001) (491 aa) fasta scores: E(): 0, 99.0% id in 491 aa, and to Escherichia coli outer membrane protein tolc precursor tolc or mtcb or muka or refI SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 89.7% id in 495 aa; Orthologue of E. coli tolC (TOLC_ECOLI); Fasta hit to TOLC_ECOLI (495 aa), 90% identity in 495 aa overlap. | 0.999 |
STY0520 | ybjZ | gene:17584541 | gene:17584934 | Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Conserved hypothetical ABC transporter; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.995 |
STY2279 | STY3546 | gene:17586186 | gene:17587393 | Conserved hypothetical protein; Similar to e.g Deinococcus radiodurans conserved hypothetical protein DR0832 TR:Q9RW37 (EMBL:AE001937) (290 aa) fasta scores: E(): 3.1e-32, 40.8% id in 272 aa, Neisseria meningitidis hypothetical protein NMA1019 TR:Q9JV30 (EMBL:AL162754) (258 aa) fasta scores: E(): 3.6e-16, 31.0% id in 261 aa and to Neisseria meningitidis hypothetical protein NMB0809 TR:Q9K018 (EMBL:AE002434) (265 aa) fasta scores: E(): 4e-15, 31.2% id in 263 aa; Orthologue of E. coli YEEZ_ECOLI; Fasta hit to YEEZ_ECOLI (274 aa), 89% identity in 274 aa overlap. | Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.647 |
STY2402 | STY0520 | gene:17586307 | gene:17584541 | Putative lipoprotein; Shows weak similarity to e.g. Pseudomonas aeruginosa outer membrane protein OprM precursor oprM or oprK SW:OPRM_PSEAE (Q51487; Q51444) (477 aa) fasta scores: E(): 7.1e-20, 25.5% id in 491 aa. Contains probable N-terminal signal sequence; Fasta hit to YJCP_ECOLI (488 aa), 37% identity in 488 aa overlap; Orthologue of E. coli yohG (YOHG_ECOLI); Fasta hit to YOHG_ECOLI (398 aa), 85% identity in 396 aa overlap. | Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.802 |
STY2402 | STY3546 | gene:17586307 | gene:17587393 | Putative lipoprotein; Shows weak similarity to e.g. Pseudomonas aeruginosa outer membrane protein OprM precursor oprM or oprK SW:OPRM_PSEAE (Q51487; Q51444) (477 aa) fasta scores: E(): 7.1e-20, 25.5% id in 491 aa. Contains probable N-terminal signal sequence; Fasta hit to YJCP_ECOLI (488 aa), 37% identity in 488 aa overlap; Orthologue of E. coli yohG (YOHG_ECOLI); Fasta hit to YOHG_ECOLI (398 aa), 85% identity in 396 aa overlap. | Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.644 |
STY2402 | ybjZ | gene:17586307 | gene:17584934 | Putative lipoprotein; Shows weak similarity to e.g. Pseudomonas aeruginosa outer membrane protein OprM precursor oprM or oprK SW:OPRM_PSEAE (Q51487; Q51444) (477 aa) fasta scores: E(): 7.1e-20, 25.5% id in 491 aa. Contains probable N-terminal signal sequence; Fasta hit to YJCP_ECOLI (488 aa), 37% identity in 488 aa overlap; Orthologue of E. coli yohG (YOHG_ECOLI); Fasta hit to YOHG_ECOLI (398 aa), 85% identity in 396 aa overlap. | Conserved hypothetical ABC transporter; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.868 |
STY2941 | STY0520 | gene:17586831 | gene:17584541 | Multidrug resistance protein B; Fasta hit to YIEO_ECOLI (475 aa), 33% identity in 424 aa overlap; Fasta hit to EMRY_ECOLI (512 aa), 63% identity in 506 aa overlap; Orthologue of E. coli emrB (EMRB_ECOLI); Fasta hit to EMRB_ECOLI (512 aa), 96% identity in 512 aa overlap; Belongs to the major facilitator superfamily. | Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.781 |
STY2941 | STY3546 | gene:17586831 | gene:17587393 | Multidrug resistance protein B; Fasta hit to YIEO_ECOLI (475 aa), 33% identity in 424 aa overlap; Fasta hit to EMRY_ECOLI (512 aa), 63% identity in 506 aa overlap; Orthologue of E. coli emrB (EMRB_ECOLI); Fasta hit to EMRB_ECOLI (512 aa), 96% identity in 512 aa overlap; Belongs to the major facilitator superfamily. | Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.640 |
STY2941 | tolC | gene:17586831 | gene:17587221 | Multidrug resistance protein B; Fasta hit to YIEO_ECOLI (475 aa), 33% identity in 424 aa overlap; Fasta hit to EMRY_ECOLI (512 aa), 63% identity in 506 aa overlap; Orthologue of E. coli emrB (EMRB_ECOLI); Fasta hit to EMRB_ECOLI (512 aa), 96% identity in 512 aa overlap; Belongs to the major facilitator superfamily. | Similar to Salmonella enteritidis outer membrane protein TolC precursor tolC SW:TOLC_SALEN (Q54001) (491 aa) fasta scores: E(): 0, 99.0% id in 491 aa, and to Escherichia coli outer membrane protein tolc precursor tolc or mtcb or muka or refI SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 89.7% id in 495 aa; Orthologue of E. coli tolC (TOLC_ECOLI); Fasta hit to TOLC_ECOLI (495 aa), 90% identity in 495 aa overlap. | 0.749 |
STY2941 | ybjZ | gene:17586831 | gene:17584934 | Multidrug resistance protein B; Fasta hit to YIEO_ECOLI (475 aa), 33% identity in 424 aa overlap; Fasta hit to EMRY_ECOLI (512 aa), 63% identity in 506 aa overlap; Orthologue of E. coli emrB (EMRB_ECOLI); Fasta hit to EMRB_ECOLI (512 aa), 96% identity in 512 aa overlap; Belongs to the major facilitator superfamily. | Conserved hypothetical ABC transporter; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.554 |
STY3545 | STY3546 | gene:17587392 | gene:17587393 | Putative membrane protein; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell; Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. | Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.983 |
STY3545 | STY3546a | gene:17587392 | gene:17587394 | Putative membrane protein; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell; Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. | Similar to Escherichia coli hypothetical protein YhcR SW:YHCR_ECOLI (P46478) (90 aa) fasta scores: E(): 5.6e-29, 98.5% id in 67 aa. | 0.968 |
STY3545 | STY3547 | gene:17587392 | gene:17587395 | Putative membrane protein; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell; Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. | Probable LysR-family transcriptional regulator; Fasta hit to YHJC_ECOLI (299 aa), 31% identity in 293 aa overlap; Fasta hit to YAFC_ECOLI (304 aa), 31% identity in 290 aa overlap; Fasta hit to YEAT_ECOLI (307 aa), 30% identity in 293 aa overlap; Orthologue of E. coli YHCS_ECOLI; Fasta hit to YHCS_ECOLI (309 aa), 95% identity in 309 aa overlap; Belongs to the LysR transcriptional regulatory family. | 0.713 |
STY3546 | STY0381 | gene:17587393 | gene:17584410 | Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Possible transcriptionl regulator; Similar to Salmonella typhimurium hypothetical 24.8 kDa protein TR:Q9RFV5 (EMBL:AF166275) (213 aa) fasta scores: E(): 0, 99.4% id in 175 aa, and to Klebsiella pneumoniae Rmpa2 rmpa2 TR:Q53343 (EMBL:S64176) (212 aa) fasta scores: E(): 1.7e-12, 31.9% id in 160 aa, and weakly to the C-terminus of Corynebacterium diphtheriae response regulator CstA cstA TR:Q9RPE7 (EMBL:AF161328) (233 aa) fasta scores: E(): 0.33, 34.3% id in 67 aa, and Salmonella typhimurium transcriptional regulatory protein UhpA uhpA SW:UHPA_SALTY (P27667) (196 aa) fasta scores: E(): 0.7 [...] | 0.656 |
STY3546 | STY0520 | gene:17587393 | gene:17584541 | Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.572 |
STY3546 | STY2279 | gene:17587393 | gene:17586186 | Possible exported protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Conserved hypothetical protein; Similar to e.g Deinococcus radiodurans conserved hypothetical protein DR0832 TR:Q9RW37 (EMBL:AE001937) (290 aa) fasta scores: E(): 3.1e-32, 40.8% id in 272 aa, Neisseria meningitidis hypothetical protein NMA1019 TR:Q9JV30 (EMBL:AL162754) (258 aa) fasta scores: E(): 3.6e-16, 31.0% id in 261 aa and to Neisseria meningitidis hypothetical protein NMB0809 TR:Q9K018 (EMBL:AE002434) (265 aa) fasta scores: E(): 4e-15, 31.2% id in 263 aa; Orthologue of E. coli YEEZ_ECOLI; Fasta hit to YEEZ_ECOLI (274 aa), 89% identity in 274 aa overlap. | 0.647 |