node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STY0581 | STY1272 | gene:17584597 | gene:17585236 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.907 |
STY0581 | STY2089 | gene:17584597 | gene:17585999 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.710 |
STY0581 | STY2592 | gene:17584597 | gene:17586491 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.984 |
STY0581 | STY2740 | gene:17584597 | gene:17586635 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | Phosphoribosylformylglycinamidine cyclo-ligase; Orthologue of E. coli purM (PUR5_ECOLI); Fasta hit to PUR5_ECOLI (344 aa), 91% identity in 344 aa overlap. | 0.999 |
STY0581 | STY2741 | gene:17584597 | gene:17586636 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | Phosphoribosylglycinamidine myltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.977 |
STY0581 | STY2752 | gene:17584597 | gene:17586647 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.689 |
STY0581 | STY2812 | gene:17584597 | gene:17586702 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | Phosphoribosylformylglycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.997 |
STY0581 | STY3709 | gene:17584597 | gene:17587569 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Orthologue of E. coli purH (PUR9_ECOLI); Fasta hit to PUR9_ECOLI (529 aa), 94% identity in 529 aa overlap. | 0.992 |
STY0581 | STY3710 | gene:17584597 | gene:17587570 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | Phosphoribosylglycineamide synthetase; Orthologue of E. coli purD (PUR2_ECOLI); Fasta hit to PUR2_ECOLI (429 aa), 94% identity in 429 aa overlap; Belongs to the GARS family. | 0.993 |
STY1272 | STY0581 | gene:17585236 | gene:17584597 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.907 |
STY1272 | STY2592 | gene:17585236 | gene:17586491 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.919 |
STY1272 | STY2740 | gene:17585236 | gene:17586635 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine cyclo-ligase; Orthologue of E. coli purM (PUR5_ECOLI); Fasta hit to PUR5_ECOLI (344 aa), 91% identity in 344 aa overlap. | 0.917 |
STY1272 | STY2741 | gene:17585236 | gene:17586636 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamidine myltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.888 |
STY1272 | STY2752 | gene:17585236 | gene:17586647 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.828 |
STY1272 | STY2802 | gene:17585236 | gene:17586692 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.702 |
STY1272 | STY2812 | gene:17585236 | gene:17586702 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.993 |
STY1272 | STY3709 | gene:17585236 | gene:17587569 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Orthologue of E. coli purH (PUR9_ECOLI); Fasta hit to PUR9_ECOLI (529 aa), 94% identity in 529 aa overlap. | 0.997 |
STY1272 | STY3710 | gene:17585236 | gene:17587570 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycineamide synthetase; Orthologue of E. coli purD (PUR2_ECOLI); Fasta hit to PUR2_ECOLI (429 aa), 94% identity in 429 aa overlap; Belongs to the GARS family. | 0.933 |
STY2089 | STY0581 | gene:17585999 | gene:17584597 | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.710 |
STY2089 | STY2592 | gene:17585999 | gene:17586491 | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.706 |