STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
STY4102Putative L-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa)    
Predicted Functional Partners:
STY4103
Putative L-lactate dehydrogenase operon regulator; Fasta hit to PDHR_ECOLI (254 aa), 39% identity in 254 aa overlap; Fasta hit to UXUR_ECOLI (257 aa), 32% identity in 235 aa overlap; Orthologue of E. coli lctR (LLDR_ECOLI); Fasta hit to LLDR_ECOLI (258 aa), 86% identity in 258 aa overlap.
 
  
 0.998
STY2397
D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family.
 
 0.987
STY1419
Similar to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbK SW:NIFJ_ECOLI (P52647; P77238) (1174 aa) fasta scores: E(): 0, 92.9% id in 1174 aa; Orthologue of E. coli NIFJ_ECOLI; Fasta hit to NIFJ_ECOLI (1174 aa), 93% identity in 1174 aa overlap.
  
 
 0.974
STY4104
L-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force (By similarity).
 
  
 0.973
STY1422
D-lactate dehydrogenase; Orthologue of E. coli ldhA (LDHD_ECOLI); Fasta hit to LDHD_ECOLI (329 aa), 95% identity in 328 aa overlap; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.958
STY2096
Pyruvate kinase A; Fasta hit to KPY1_ECOLI (470 aa), 37% identity in 480 aa overlap; Orthologue of E. coli pykA (KPY2_ECOLI); Fasta hit to KPY2_ECOLI (479 aa), 98% identity in 479 aa overlap; Belongs to the pyruvate kinase family.
   
 0.933
maeB
NADP-dependent malate dehydrogenase (decarboxylating); Similar to Escherichia coli NADP-dependent malic enzyme maeB SW:MAO2_ECOLI (P76558) (759 aa) fasta scores: E(): 0, 94.3% id in 759 aa; Orthologue of E. coli MAO2_ECOLI; Fasta hit to MAO2_ECOLI (759 aa), 94% identity in 759 aa overlap.
    
 0.931
STY0175
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.921
STY1744
Pyruvate kinase; Fasta hit to KPY2_ECOLI (479 aa), 38% identity in 480 aa overlap; Orthologue of E. coli pykF (KPY1_ECOLI); Fasta hit to KPY1_ECOLI (470 aa), 96% identity in 470 aa overlap.
   
 0.920
STY0931
Pyruvate dehydrogenase; Fasta hit to ILVI_ECOLI (574 aa), 30% identity in 560 aa overlap; Orthologue of E. coli poxB (POXB_ECOLI); Fasta hit to POXB_ECOLI (572 aa), 94% identity in 572 aa overlap; Belongs to the TPP enzyme family.
  
 
 0.913
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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