STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY41603-methyladenine DNA glycosylase I, constitutive; Orthologue of E. coli tag (3MG1_ECOLI); Fasta hit to 3MG1_ECOLI (187 aa), 85% identity in 186 aa overlap. (193 aa)    
Predicted Functional Partners:
STY4159
Putative acetyltransferase; Fasta hit to YJAB_ECOLI (147 aa), 34% identity in 134 aa overlap; Orthologue of E. coli yiaC (YIAC_ECOLI); Fasta hit to YIAC_ECOLI (146 aa), 60% identity in 145 aa overlap.
       0.835
STY1405
O6-methylguanine-DNA-alkyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
   
 0.725
STY3881
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.629
STY4161
Putative membrane protein; Similar to the C-terminal halves of Salmonella typhimurium outer membrane esterase apeE TR:O52756 (EMBL:AF047014) (656 aa) fasta scores: E(): 4.3e-12, 26.5% id in 234 aa and Photorhabdus luminescens lipase 1 precursor lip-1 SW:LIP1_PHOLU (P40601) (645 aa) fasta scores: E(): 1.4e-11, 28.0% id in 150 aa. Contains an hydrophobic, possible membrane-spanning region; Orthologue of E. coli yhjY (P76714); Fasta hit to P76714 (234 aa), 72% identity in 235 aa overlap.
  
    0.570
STY2491
ADA regulatory protein; Similar to Salmonella typhimurium regulatory protein adA SW:ADA_SALTY (P26189) (352 aa) fasta scores: E(): 0, 98.6% id in 352 aa; Orthologue of E. coli ada (ADA_ECOLI); Fasta hit to ADA_ECOLI (354 aa), 75% identity in 353 aa overlap.
 
   
 0.515
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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