STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phoNSimilar to Salmonella typhimurium nonspecific acid phosphatase precursor phoN SW:PHON_SALTY (P26976) (250 aa) fasta scores: E(): 0, 94.8% id in 250 aa. (250 aa)    
Predicted Functional Partners:
aphA
Class B acid phosphatase precursor; Dephosphorylates several organic phosphate monoesters including monophosphate nucleotides (NMPs), coenzyme A (CoA), nicotinamide adenine dinucleotide phosphate (NADP), flavin mononucleotide (FMN) and phosphorylated 5-6 carbon sugars in vitro. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity).
     
 0.925
STY3609
Conserved hypothetical protein; Orthologue of E. coli yigB (YIGB_ECOLI); Fasta hit to YIGB_ECOLI (238 aa), 87% identity in 238 aa overlap.
 
  
  0.918
virK
Virulence protein; Identical to Salmonella typhi AJB70 VirK protein TR:O68287 (EMBL:AF029845) (297 aa) fasta scores: E(): 0, 100.0% id in 297 aa. Similar to Salmonella typhimurium SL1344 protein VirK TR:AAB80743 (EMBL:AF020810) (294 aa) fasta scores: E(): 0, 99.3% id in 294 aa; Paralogue of E. coli YBJX_ECOLI; Fasta hit to YBJX_ECOLI (330 aa), 37% identity in 318 aa overlap.
  
  
 0.916
ribF
Similar to Escherichia coli riboflavin biosynthesis protein RibF [includes: riboflavin kinase; FMN adenylyltransferase] RIBF SW:RIBF_ECOLI (P08391; P75621) fasta scores: E(): 0, 90.0% id in 309 aa, and to Pseudomonas fluorescens riboflavin biosynthesis protein ribf [includes: riboflavin kinase; FMN adenylyltransferase] RIBF SW:RIBF_PSEFL (P22990) fasta scores: E(): 0, 52.6% id in 304 aa; Orthologue of E. coli yaaC (RIBF_ECOLI); Fasta hit to RIBF_ECOLI (313 aa), 90% identity in 309 aa overlap.
     
  0.900
STY0900
Similar to Escherichia coli hypothetical protein YbjI SW:YBJI_ECOLI (P75809) (271 aa) fasta scores: E(): 0, 83.7% id in 270 aa, and to Bacillus subtilis hypothetical protein YitU TR:P70947 (EMBL:Z79580) (270 aa) fasta scores: E(): 5.7e-10, 25.6% id in 270 aa.
     
  0.900
hpaC
4-hydroxyphenylacetate 3-monooxygenase coupling protein; Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component or to other electron acceptors such as cytochrome c and Fe(3+) ion (By similarity); Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily.
     
  0.900
STY1696
Riboflavin synthase alpha chain; Orthologue of E. coli ribE (RISA_ECOLI); Fasta hit to RISA_ECOLI (213 aa), 90% identity in 209 aa overlap.
     
  0.900
STY3580
Flavin reductase; Orthologue of E. coli ubiB (UBIB_ECOLI); Fasta hit to UBIB_ECOLI (232 aa), 91% identity in 232 aa overlap.
     
  0.900
STY2897
Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...]
   
  
 0.510
STY2869
Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
     
  0.499
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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